PMID: 8599993Jan 1, 1996Paper

Angiogenesis spectrum in the stroma of B-cell non-Hodgkin's lymphomas. An immunohistochemical and ultrastructural study

European Journal of Haematology
D RibattiF Dammacco

Abstract

Samples of lymph nodes from 88 patients with B-cell non-Hodgkin's lymphoma (B-NHL) grouped by the Working Formulation (WF) and from 15 patients with benign lymphadenopathies were investigated immunohistochemically and ultrastructurally for changes in angiogenesis and stromal distribution of two subendothelial basement membrane (BM) components, namely laminin and type IV collagen. The microvessel number was usually low in lymphadenopathies, and increased significantly in low-grade B-NHL. Intermediate-grade tumors displayed a further significant increase that was mainly due to their diffuse subtypes rather than to the follicular subtype. High-grade B-NHL showed the highest counts. By contrast with the lymphadenopathies studied, the stroma of B-NHL reacted intensely with both BM components, whose linear co-expression was significantly associated with low-grade and follicular intermediate-grade B-NHL, while expression of laminin alone in a granular pattern was detected in diffuse intermediate-grade and high-grade tumors. Ultrastructural analysis revealed immature vessels more frequently in diffuse intermediate-grade, and in high-grade B-NHL. These in situ data suggest that angiogenesis occurring in B-NHL increases along their progr...Continue Reading

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Citations

Feb 20, 2003·British Journal of Cancer·E PassalidouF Pezzella
Dec 14, 2004·Stem Cells and Development·Domenico RibattiAngelo Vacca
Apr 29, 2014·Histopathology·Alessandro PileriPier Paolo Piccaluga
Dec 17, 2014·Immunological Reviews·Yawara KawanoIrene M Ghobrial
Mar 30, 2000·Journal of Hematotherapy & Stem Cell Research·D RibattiF Dammacco
Nov 25, 2000·British Journal of Haematology·M H Mangi, A C Newland
Sep 5, 2002·The Journal of Pathology·Ipatia A Doussis-AnagnostopoulouKevin C Gatter
Nov 1, 2002·Current Opinion in Oncology·William T Bellamy
Mar 29, 2003·Journal of Hematotherapy & Stem Cell Research·Domenico RibattiDenis English
Jan 2, 2014·Molecular Biology Reports·Zhanshan ChaBaohua Qian
Feb 16, 2002·Journal of Hematotherapy & Stem Cell Research·Roberto Stasi, Sergio Amadori
May 10, 2002·Leukemia & Lymphoma·Arto Orpana, Petri Salven
May 10, 2002·International Journal of Hematology·Renchi Yang, Zhong Chao Han
Jul 11, 2000·British Journal of Haematology·K L Talks, A L Harris
Feb 16, 2002·Journal of Hematotherapy & Stem Cell Research·S Vincent RajkumarAyalew Tefferi
May 3, 2008·Leukemia & Lymphoma·Sonia ValletKenneth C Anderson
Jul 3, 1998·European Journal of Clinical Investigation·D RibattiL Selvaggi

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