Angiogenesis, tumor necrosis factor-alpha and procoagulant factors in coronary artery giant aneurysm of a fatal infantile Kawasaki disease

Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology
Angela PucciGiovanni Bartoloni

Abstract

Kawasaki disease (KD) is an infantile febrile illness of unknown origin characterized by clinical, laboratory and histopathologic features of systemic vasculitis. We report a 3-month-old female infant with incomplete KD who suddenly died despite intravenous immunoglobulin, aspirin, steroid and heparin treatment. Postmortem examination confirmed the echocardiographically detected giant coronary aneurysms and showed occlusive thrombosis in the giant aneurysm of the left anterior descending coronary artery, associated with neoangiogenesis, macrophage infiltration and immunostaining for tissue factor (a strong initiator of the coagulation cascade), thrombopoietin receptor and tumour necrosis factor-alpha. These findings show the association of angiogenesis, tumor necrosis factor-alpha and procoagulant factors, with macrophage infiltration in coronary artery aneurysms of a fatal infantile KD.

References

Mar 1, 1995·The Pediatric Infectious Disease Journal·B A EberhardE D Silverman
Aug 13, 2003·Pediatrics International : Official Journal of the Japan Pediatric Society·Yosikazu NakamuraHiroshi Yanagawa
May 8, 2004·The Pediatric Infectious Disease Journal·Alexandra F Freeman, Stanford T Shulman
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Sep 1, 2005·Pediatric Cardiology·A F FreemanA H Rowley
Aug 11, 2006·Journal of Paediatrics and Child Health·Kyung-Yil LeeDavid Burgner

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Citations

May 14, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Kenji SudaToyojiro Matsuishi
Mar 5, 2010·Fundamental & Clinical Pharmacology·Shraddha V BhadadaMayur M Patel
Dec 17, 2008·Current Opinion in Rheumatology

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