Angiogenic activity of sesamin through the activation of multiple signal pathways

Biochemical and Biophysical Research Communications
Byung-Hee ChungYoung-Myeong Kim

Abstract

The natural product sesamin has been known to act as a potent antioxidant and prevent endothelial dysfunction. We here found that sesamin increased in vitro angiogenic processes, such as endothelial cell proliferation, migration, and tube formation, as well as neovascularization in an animal model. This compound elicited the activation of multiple angiogenic signal modulators, such as ERK, Akt, endothelial nitric oxide synthase (eNOS), NO production, FAK, and p38 MAPK, but not Src. The MEK inhibitor PD98059 and the PI3K inhibitor Wortmannin specifically inhibited sesamin-induced activation of the ERK and Akt/eNOS pathways. These inhibitors reduced angiogenic events, with high specificity for MEK/ERK-dependent cell proliferation and migration and PI3K/Akt-mediated tube formation. Moreover, inhibition of p38 MAPK effectively inhibited sesamin-induced cell migration. The angiogenic activity of sesamin was not associated with VEGF expression. Furthermore, this compound did not induce vascular permeability and upregulated ICAM-1 and VCAM-1 expression, which are hallmarks of vascular inflammation. These results suggest that sesamin stimulates angiogenesis in vitro and in vivo through the activation of MEK/ERK-, PI3K/Akt/eNOS-, p125(F...Continue Reading

References

Jul 1, 1995·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·E J Battegay
Jul 1, 1997·Trends in Biochemical Sciences·F BussolinoG Persico
May 25, 2002·The Journal of Biological Chemistry·Young-Mi KimYoung-Guen Kwon
Sep 1, 2004·Cellular and Molecular Life Sciences : CMLS·R Muñoz-ChápuliM Angel Medina
Jan 18, 2006·Annual Review of Medicine·Judah Folkman
Aug 1, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Seon-Jin LeeYoung-Myeong Kim
Sep 16, 2008·Biochemical and Biophysical Research Communications·Byung-Hee ChungYoung-Myeong Kim

❮ Previous
Next ❯

Citations

May 14, 2016·Brain Research·Wilma Helena OliveiraChristina Alves Peixoto
Jan 1, 2015·Phytochemistry Reviews : Proceedings of the Phytochemical Society of Europe·Kristýna Schneiderová, Karel Šmejkal
Feb 6, 2021·Critical Reviews in Food Science and Nutrition·Amin F MajdalawiehGheyath K Nasrallah
Nov 3, 2020·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Sarah DalibaltaHerak Manjikian

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.