Abstract
The natural product sesamin has been known to act as a potent antioxidant and prevent endothelial dysfunction. We here found that sesamin increased in vitro angiogenic processes, such as endothelial cell proliferation, migration, and tube formation, as well as neovascularization in an animal model. This compound elicited the activation of multiple angiogenic signal modulators, such as ERK, Akt, endothelial nitric oxide synthase (eNOS), NO production, FAK, and p38 MAPK, but not Src. The MEK inhibitor PD98059 and the PI3K inhibitor Wortmannin specifically inhibited sesamin-induced activation of the ERK and Akt/eNOS pathways. These inhibitors reduced angiogenic events, with high specificity for MEK/ERK-dependent cell proliferation and migration and PI3K/Akt-mediated tube formation. Moreover, inhibition of p38 MAPK effectively inhibited sesamin-induced cell migration. The angiogenic activity of sesamin was not associated with VEGF expression. Furthermore, this compound did not induce vascular permeability and upregulated ICAM-1 and VCAM-1 expression, which are hallmarks of vascular inflammation. These results suggest that sesamin stimulates angiogenesis in vitro and in vivo through the activation of MEK/ERK-, PI3K/Akt/eNOS-, p125(F...Continue Reading
References
Jul 1, 1995·Biological & Pharmaceutical Bulletin·Y MatsumuraT Tanaka
Jan 1, 1993·Annals of Nutrition & Metabolism·K AkimotoH Yamada
Jul 1, 1995·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·E J Battegay
Jul 1, 1997·Trends in Biochemical Sciences·F BussolinoG Persico
Apr 1, 2000·The Journal of Biological Chemistry·S RousseauJ Huot
May 25, 2002·The Journal of Biological Chemistry·Young-Mi KimYoung-Guen Kwon
Oct 23, 2002·Planta medica·Sanghyun LeeBak-Kwang Kim
Dec 4, 2003·Biological & Pharmaceutical Bulletin·Daisuke NakanoYasuo Matsumura
Sep 1, 2004·Cellular and Molecular Life Sciences : CMLS·R Muñoz-ChápuliM Angel Medina
Jan 1, 2005·Immunology Letters·Kee-Ching G JengLing-In Ping
Jan 18, 2006·Annual Review of Medicine·Judah Folkman
Apr 7, 2006·The Journal of Pharmacology and Experimental Therapeutics·Daisuke NakanoYasuo Matsumura
Aug 1, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Seon-Jin LeeYoung-Myeong Kim
Oct 14, 2006·Blood·Jeong-Ki MinYoung-Guen Kwon
Oct 25, 2006·Nature Cell Biology·Julie Gavard, J Silvio Gutkind
Sep 16, 2008·Biochemical and Biophysical Research Communications·Byung-Hee ChungYoung-Myeong Kim
Citations
Feb 22, 2012·Breast Cancer Research and Treatment·Neng WangJian-Ping Chen
Feb 5, 2011·Acta Pharmacologica Sinica·Hai-yan ZhangJun-ying Miao
Oct 4, 2013·Biological & Pharmaceutical Bulletin·Pengyi DengGuangyuan He
Dec 16, 2011·Experimental & Molecular Medicine·Byung-Hee ChungYoung-Myeong Kim
Jul 6, 2014·PloS One·Zhe-Rui ZhangRen-Wang Jiang
Mar 1, 2012·Vascular Pharmacology·Toshihiro KagaRyuichi Morishita
Dec 24, 2014·Chinese Journal of Integrative Medicine·Bin-Rui YangZhi-Xiu Lin
May 14, 2016·Brain Research·Wilma Helena OliveiraChristina Alves Peixoto
Nov 14, 2014·The Journal of Biological Chemistry·Young-Lai ChoYoung-Myeong Kim
Jan 9, 2019·Frontiers in Physiology·Shuang DengHao Peng
Jan 1, 2015·Phytochemistry Reviews : Proceedings of the Phytochemical Society of Europe·Kristýna Schneiderová, Karel Šmejkal
Jul 19, 2019·Frontiers in Pharmacology·Dimitris MichailidisLéandros Skaltsounis
Sep 20, 2019·Oxidative Medicine and Cellular Longevity·Xupeng BaiJing Jin
Feb 6, 2021·Critical Reviews in Food Science and Nutrition·Amin F MajdalawiehGheyath K Nasrallah
Nov 3, 2020·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Sarah DalibaltaHerak Manjikian
Dec 6, 2014·Journal of Natural Products·Zsanett HajduDezső Csupor
Oct 26, 2021·Frontiers in Chemistry·Anuj KumarDinesh Kumar