Angiogenic biomarkers in pregnancy: defining maternal and fetal health

Acta Obstetricia Et Gynecologica Scandinavica
Lene G RasmussenAnne Cathrine Staff

Abstract

We review diagnostic and predictive roles of the angiogenic proteins placental growth factor, soluble fms-like tyrosine kinase 1, and soluble endoglin in preeclampsia, and their association with future cardiovascular disease, diabetes, and breast cancer. Specific patterns of these proteins represent preeclamptic prediction markers and combined with maternal and clinical characteristics, the predictive values increase. Women experiencing preeclampsia have increased risks of developing cardiovascular diseases and diabetes, and a decreased risk of breast cancer. High placental growth factor concentrations have, in elderly patients, been shown to predict cardiovascular events. Diabetes is also a risk factor for future cardiovascular disease. Diabetic vascular complications are associated with increased soluble endoglin concentrations, and vascular endothelial growth factor concentrations are correlated to HbA1c and fasting glucose. Hence dysregulation in angiogenic proteins may link preeclampsia and cardiovascular diseases, targeting women who could in future benefit from prophylactic programs to possibly prevent, delay or reduce cardiovascular disease.

References

Nov 4, 1992·Journal of the National Cancer Institute·M C KibbeyH K Kleinman
Aug 1, 1990·American Journal of Obstetrics and Gynecology·P R GarnerM Hardie
Nov 1, 1995·Acta Obstetricia Et Gynecologica Scandinavica·L S JónsdóttirN Sigfússon
Jul 9, 1998·Seminars in Reproductive Endocrinology·R Kaaja
Nov 3, 1998·Epidemiology·R TroisiL A Brinton
Feb 13, 1999·American Journal of Obstetrics and Gynecology·C W RedmanI L Sargent
Jul 6, 2000·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·V J RoachM S Rogers
Jun 2, 2001·Lancet·A H ShennanP T Seed
Aug 2, 2001·Journal of the National Cancer Institute·B A CohnP K Siiteri
Sep 29, 2001·Obstetrics and Gynecology·M L TjoaI J van Wijk
Nov 24, 2001·BMJ : British Medical Journal·H U IrgensR T Lie
Nov 16, 2002·British Journal of Cancer·L J VattenR Skjaerven
Jan 28, 2003·American Journal of Obstetrics and Gynecology·Robert N TaylorRobyn A North
Mar 12, 2003·The Journal of Clinical Endocrinology and Metabolism·Sirpa TenholaRaimo Voutilainen
Jun 6, 2003·The Journal of Clinical Endocrinology and Metabolism·Ellen W Seely, Caren G Solomon
Nov 19, 2003·Current Opinion in Obstetrics & Gynecology·David Williams
Jan 30, 2004·JAMA : the Journal of the American Medical Association·Christopher HeeschenUNKNOWN CAPTURE Investigators
Feb 7, 2004·The Journal of Clinical Endocrinology and Metabolism·Ravi ThadhaniS Ananth Karumanchi
Feb 7, 2004·The New England Journal of Medicine·Richard J LevineS Ananth Karumanchi
Sep 8, 2004·International Journal of Cancer. Journal International Du Cancer·Kim E Innes, Tim E Byers
Nov 19, 2004·The New England Journal of Medicine·Holger StepanRenaldo Faber
Dec 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Myles WolfRavi Thadhani
Dec 23, 2004·Journal of Hypertension·Anne BardenLawrence J Beilin
Jan 6, 2005·JAMA : the Journal of the American Medical Association·Richard J LevineS Ananth Karumanchi
Feb 17, 2005·BJOG : an International Journal of Obstetrics and Gynaecology·Gerdur A ArnadottirOrn Olafsson
Mar 4, 2005·BMJ : British Medical Journal·Kirsten Duckitt, Deborah Harrington
Jun 7, 2005·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Anne Cathrine StaffMette R Holthe
Jun 11, 2005·Science·Christopher W Redman, Ian L Sargent
Oct 18, 2005·BJOG : an International Journal of Obstetrics and Gynaecology·Anna-Karin WikströmSolveig Nordén Lindeberg
Nov 9, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Christian ParrWen G Jiang
Jan 18, 2006·Journal of the American College of Cardiology·Timo LenderinkUNKNOWN CAPTURE Investigators
May 24, 2006·The Journal of Pharmacology and Experimental Therapeutics·Gabriella PridjianJules B Puschett
Jun 6, 2006·Nature Medicine·Shivalingappa VenkateshaS Ananth Karumanchi
Sep 5, 2006·American Journal of Obstetrics and Gynecology·Kjersti M Aagaard-TilleryMichael W Varner
Sep 8, 2006·The New England Journal of Medicine·Richard J LevineUNKNOWN CPEP Study Group
Sep 8, 2006·The New England Journal of Medicine·Sebastian J Padayatty, Mark Levine
Mar 7, 2007·Expert Review of Cardiovascular Therapy·J NewsteadLaura A Magee
Mar 10, 2007·American Journal of Obstetrics and Gynecology·Lars J VattenAnne Cathrine Staff
Apr 20, 2007·The Cochrane Database of Systematic Reviews·L DuleyJ F King
Nov 3, 2007·BMJ : British Medical Journal·Leanne BellamyDavid J Williams
Nov 21, 2007·Lancet·M ChandiramaniA H Shennan

❮ Previous
Next ❯

Citations

Feb 3, 2016·Scientific Reports·Natalia E PovedaJorge E Caminos
Oct 31, 2015·Human Reproduction·M M ReigstadR Storeng
Feb 27, 2016·International Journal of Cancer. Journal International Du Cancer·Ida BehrensHeather Allison Boyd
Nov 15, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Emre ZaferHasan Yuksel
Dec 13, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Tania T HerreraGabrielle B Britton
Oct 24, 2017·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Hakan ErenelAbdullah Tuten
May 21, 2016·Circulation Research·Lukasz PrzybylFlorian Herse
Mar 5, 2021·Journal of Reproductive Immunology·Sarah MeisterThomas Kolben

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Diabetes

This feed focuses on the latest research on biomarkers used for monitoring disease progression in diabetes.

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Cardiovascular Disorder in Diabetes

Diabetes is associated with an increased risk of cardiovascular disorders and heart failure. Discover the latest research here.

Related Papers

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Bonnie K DwyerMaurice Druzin
PloS One
Arun JeyabalanEunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network
© 2022 Meta ULC. All rights reserved