Angiogenic cytokines in induced sputum of patients with sarcoidosis

Respirology : Official Journal of the Asian Pacific Society of Respirology
E FiremanSilvia Marmor

Abstract

Sarcoidosis is a systemic granulomatous disorder of unknown aetiology involving multiple organs and often associated with non-granulomatous microangiopathic lesions in various organs. Increased angiogenesis-inducing ability of activated alveolar macrophages was found in bronchoalveolar specimens from patients with pulmonary sarcoidosis and from patients with extrapulmonary involvement. In contrast, decreased levels of vascular endothelial growth factor (VEGF) were found in BAL fluid recovered from sarcoid-associated pulmonary fibrosis. This study evaluated whether sarcoidosis is associated with abnormalities of VEGF and IL-8 in induced sputum (IS) samples. Twenty-three sarcoid patients and 13 controls performed IS. CD4/CD8 T-cell subsets were measured, as were pulmonary function tests and VEGF and IL-8. Sarcoid patients showed significantly higher mean %lymphocytes (P = 0.04), significantly higher mean CD4/CD8 ratio (P = 0.0001) and significantly lower VEGF levels (P = 0.03) than controls. Patients with stages III-IV sarcoidosis showed a lower level of VEGF compared with those with stages I-II sarcoidosis (P = 0.048). IL-8 was detected in 10/35 samples and positively correlated with % neutrophils (P = 0.054) and eosinophils (P ...Continue Reading

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Citations

Apr 9, 2009·Respirology : Official Journal of the Asian Pacific Society of Respirology·Martin R J Kolb, Ian Yang
Mar 5, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Peter R EastwoodBing Lam
May 21, 2009·European Journal of Clinical Investigation·N KokturkE Fireman
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Feb 22, 2012·Blood Pressure·Idris ArdicMehmet Gungor Kaya
Nov 26, 2009·Current Opinion in Rheumatology

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