Angiogenic cytokines profile in smoldering multiple myeloma: no difference compared to MGUS but altered compared to symptomatic myeloma

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Maria GkotzamanidouEvangelos Terpos

Abstract

Symptomatic multiple myeloma (MM) evolves from an asymptomatic precursor state termed monoclonal gammopathy of undetermined significance (MGUS) and smoldering myeloma (SMM). Angiogenesis plays a key role in the pathogenesis of MM but there are very limited data for angiogenesis in SMM. We measured the circulating levels of angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2), vascular endothelial growth factor (VEGF), and angiogenin in 54 patients with SMM. The results were compared with those of 27 MGUS patients, 55 MM patients, and 22 healthy controls. The expression of VEGF-A gene was also evaluated in 10 patients with SMM, 10 with symptomatic MM, and 10 with MGUS. The ratio of circulating Ang-1/Ang-2 was reduced in MM patients with symptomatic disease due to a dramatic increase of Ang-2 (p<0.001), but not in patients with SMM or MGUS, in whom it did not differ compared to controls. VEGF and angiogenin were increased in all patients compared to controls. However, circulating VEGF was higher in symptomatic MM compared to SMM and MGUS, while angiogenin was reduced. There were no differences in the expression of VEGF-A among the 3 patients categories. SMM has a circulating angiogenic cytokine profile similar to that of MGUS, but has ...Continue Reading

References

Jul 1, 1994·British Journal of Haematology·A VaccaF Dammacco
Jun 5, 2003·Nature Medicine·Peter Carmeliet
Sep 27, 2003·Leukemia·S KumarS V Rajkumar
Nov 26, 2003·Circulation·Neil P FamDuncan J Stewart
May 3, 2005·Cytokine & Growth Factor Reviews·Marco PrestaMarco Rusnati
Nov 9, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jean-Paul FermandUNKNOWN Group Myelome-Autogreffe
Jan 25, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bart BarlogieJohn C Crowley
Sep 12, 2006·Journal of Thrombosis and Haemostasis : JTH·A Tello-MontoliuG Y H Lip
Sep 19, 2006·European Journal of Haematology·E QuartaroneC Musolino
Feb 6, 2007·Clinical Immunology : the Official Journal of the Clinical Immunology Society·P P SfikakisA N Theofilopoulos
Apr 10, 2008·Leukemia & Lymphoma·Konstantinos AnargyrouEvangelos Terpos
May 9, 2008·The New England Journal of Medicine·Robert S Kerbel
Jan 26, 2011·Annual Review of Pathology·Kenneth C Anderson, Ruben D Carrasco
Apr 13, 2011·International Journal of Cancer. Journal International Du Cancer·Evangelos TerposUNKNOWN Greek Myeloma Study Group, Greece
Jan 22, 2013·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal

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Citations

Nov 4, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Zun-Chang LiHong-Jie Fu

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Methods Mentioned

BETA
flow cytometry
electrophoresis
PCR

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