Angiogenic dysfunction in molar pregnancy.

American Journal of Obstetrics and Gynecology
David KanterIsaac E Stillman

Abstract

Molar pregnancy is associated with very early-onset preeclampsia. Since excessive circulating antiangiogenic factors may play a pathogenic role in preeclampsia, we hypothesized that molar placentas produce more antiangiogenic proteins than normal placentas. This retrospective case-control study used a semiquantitative immunohistochemical technique to compare histologic sections of molar placentas to normal controls. Tissue slides were treated with 2 antisera: one recognized the antiangiogenic markers fms-like tyrosine kinase receptor 1 (Flt1) and its soluble form (sFlt1), while the other recognized vascular endothelial marker CD31. Stain intensity was graded from 1+ (strong focal staining) to 4+ (91-100% staining). Molar placentas (n = 19) showed significantly more staining than controls (n = 16) for Flt/sFlt1 (P < .0001). There was a significant difference in Flt1/sFlt1 immunostaining intensity when molar placentas were compared to controls. This supports a hypothesis that the phenotype of preeclampsia in molar pregnancy may result from trophoblasts overproducing at least 1 antiangiogenic protein.

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Citations

Aug 4, 2011·Reproductive Biology and Endocrinology : RB&E·Haruki NishizawaYasuhiro Udagawa
Aug 10, 2013·Advances in Chronic Kidney Disease·Mihran V Naljayan, S Ananth Karumanchi
Jan 27, 2011·Seminars in Nephrology·Sharon E Maynard, S Ananth Karumanchi
Aug 6, 2010·Obstetrics and Gynecology Clinics of North America·Michelle SilasiSarosh Rana
Dec 7, 2013·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Yuval BdolahDrorith Hochner-Celnikier
Dec 14, 2011·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Kristin BixelSarosh Rana
Mar 16, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Tamara StampalijaSonia S Hassan
Sep 18, 2012·American Journal of Obstetrics and Gynecology·Thomas F McElrathSamuel Parry
Apr 22, 2011·American Journal of Obstetrics and Gynecology·Michelle SilasiIsaac E Stillman
Jun 29, 2011·Pregnancy Hypertension·Isha Agarwal, S Ananth Karumanchi
Apr 14, 2016·Hypertension·S Ananth Karumanchi
Mar 6, 2019·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·M BarjaktarovicE A P Steegers
Dec 26, 2018·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Emma M RosenKelly K Ferguson
Oct 23, 2020·Heliyon·Cynthia MartinezRaul Díaz-Molina
Oct 24, 2020·American Journal of Obstetrics and Gynecology·Sarosh RanaS Ananth Karumanchi

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