Angiogenic effects of extracellular human immunodeficiency virus type 1 Tat protein and its role in the pathogenesis of AIDS-associated Kaposi's sarcoma.

Clinical Microbiology Reviews
G Barillari, B Ensoli

Abstract

The Tat protein of human immunodeficiency virus (HIV) type 1 is a transactivator of viral gene expression that is required for virus replication and spread. Moreover, Tat is released by acutely HIV-infected cells via a leaderless secretory pathway and in a biologically active form that exerts effects on both HIV-infected and uninfected cells from different organs and systems. This review focuses on the activities of extracellular Tat protein on endothelial cells, on angiogenesis, and on the pathogenesis of AIDS-associated angioproliferative diseases such as Kaposi's sarcoma. In particular, we discuss results from different groups indicating that Tat mimics the proangiogenic activities of extracellular matrix molecules and that it enhances the effects of angiogenic factors.

References

Oct 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·J P TaylorS Amini
Sep 30, 1992·Biochemical and Biophysical Research Communications·B I TermanP Böhlen
Mar 31, 1992·Biochemical and Biophysical Research Communications·K WeindelH A Weich
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·F CozzolinoD M Stern
Feb 1, 1991·Journal of Virology·J M SabatierE Bahraoui
Oct 1, 1990·Current Opinion in Cell Biology·B R Zetter, S E Brightman
Mar 1, 1991·The Journal of Clinical Investigation·J KekowM Lotz
Jul 1, 1990·AIDS Research and Human Retroviruses·A CarusoA Turano
May 1, 1990·The Journal of Cell Biology·D E IngberM A Schwartz
Jan 1, 1990·Medical Microbiology and Immunology·U WielandR W Braun
Jan 1, 1989·Cancer Investigation·M J HumphriesK M Yamada
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A D FrankelD Hudson
Aug 11, 1989·Cell·B R Cullen, W C Greene
Jun 1, 1985·The Journal of Cell Biology·E G HaymanE Ruoslahti
Jun 1, 1989·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·A OxholmK Bendtzen
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A BairdR Guillemin
Dec 6, 1986·Lancet·J J Brooks
Sep 1, 1987·Journal of Clinical Microbiology·J L Lepe-ZunigaE M Hersh
Nov 1, 1985·Annals of Internal Medicine·B SafaiB Dupont
Jul 15, 1985·International Journal of Cancer. Journal International Du Cancer·L KestensP L Gigase
Jun 1, 1969·British Journal of Cancer·G SlavinH Singh
Oct 1, 1981·Journal of the American Academy of Dermatology·A E Friedman-Kien
Dec 1, 1995·Science·M FriedlanderD A Cheresh
Apr 22, 1994·Science·P C BrooksD A Cheresh

❮ Previous
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Citations

May 28, 2004·Trends in Molecular Medicine·Maria F Czyzyk-Krzeska, Jaroslaw Meller
Sep 10, 2003·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Giovanni BarillariBarbara Ensoli
Jun 19, 2008·BMC Cell Biology·Donatella PontiFranca Gigliani
Feb 26, 2004·Nucleic Acids Research·Dineshkumar H DandekarDebashis Mitra
Jun 24, 2009·Archives of Internal Medicine·Nancy Crum-CianfloneBrian K Agan
Apr 7, 2010·The Journal of Clinical Investigation·Don Ganem
Aug 31, 2010·American Journal of Respiratory Cell and Molecular Biology·Navneet K DhillonAmy O'Brien Ladner
Jun 15, 2011·Current Opinion in Infectious Diseases·Soren Gantt, Corey Casper
Jun 16, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Samuel M CohenJon C Cook
Apr 28, 2010·Annual Review of Microbiology·John T Schiller, Douglas R Lowy
Oct 9, 2009·International Reviews of Immunology·Antonella CaputoBarbara Ensoli
Aug 2, 2002·Expert Opinion on Investigational Drugs·Roger G Ptak
Apr 27, 2011·Expert Opinion on Pharmacotherapy·Cecilia SgadariBarbara Ensoli
Jun 28, 2006·European Journal of Haematology·Mahmoud IsmailWolfgang Dubiel
May 4, 2011·Reviews in Medical Virology·Kristof VranckenSandra Liekens
Apr 15, 2011·Journal of Experimental & Clinical Cancer Research : CR·Francesco M SolivettiAldo Di Carlo
Nov 14, 2008·Journal of Dermatological Science·Filiberto Cedeno-LaurentJ Roberto Trujillo
Jun 27, 2007·FEBS Letters·Tat San LauDavid Chi Cheong Wan
Feb 5, 2013·Neurochemistry International·Randall L DavisCraig W Stevens
Jan 29, 2016·American Journal of Respiratory Cell and Molecular Biology·Pranjali DalviNavneet K Dhillon
Nov 28, 2007·Annual Review of Pathology·Don Ganem
Sep 28, 2010·Biochemical and Biophysical Research Communications·Davide GibelliniMaria Carla Re
Jul 11, 2003·Hematology/oncology Clinics of North America·Susan E Krown
Nov 25, 2004·Current Opinion in Biotechnology·Flavia FerrantelliBarbara Ensoli
Apr 11, 2017·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Robert DubrowUNKNOWN North American AIDS Cohort Collaboration on Research and Design of the International Epidemiologic Databases to Evaluate AID
Oct 7, 2003·Oncogene·C BellanL Leoncini
Feb 11, 2016·World Journal of Clinical Oncology·Clarke Brian Blackadar
Mar 1, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Chiara UrbinatiMarco Rusnati

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