Angiogenic effects of suture biomaterials. An experimental study in rats

European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
D FoschiE Trabucchi

Abstract

Angiogenesis is a limiting step of inflammation and wound healing. Although laboratory tests for the evaluation of the angiogenetic effects of biomaterials are available, no investigations have been performed. In this study we examine the angiogenetic effect of suture biomaterials in the rat mesenteric window model. Absolute controls had laparotomy only, controls had mesenteric window wounding, test groups had the insertion of either a thread of collagen, polyglactin 910, polyglycolic acid salt, silk or of a titanium clip. We considered the percentage area of the mesenteric window covered by neovessels. After 7 days, negligible angiogenesis was found in absolute controls, significant angiogenesis in controls, collagen, polyglactin 910 and polyglycolic acid salt treated rats, without differences between treatments. A significant increase of angiogenesis in comparison to the control group was found in rats treated with silk and titanium. Ultramicroscopy of the neovessels showed specific changes of their architecture in titanium-treated rats. In conclusion, angiogenesis during wound healing is differently influenced by the suture material used. Silk and titanium stimulated angiogenesis in a different way.

Citations

Nov 9, 2002·Biomaterials·Gregory H AltmanDavid L Kaplan
Jul 12, 2011·Tissue Engineering. Part C, Methods·Frank TavassolNils-Claudius Gellrich
Jul 17, 2004·Journal of Biomaterials Science. Polymer Edition·Zarana S Patel, Antonios G Mikos
Nov 13, 2010·Folia Histochemica Et Cytobiologica·Monika Łukomska-SymańskaJerzy Sokołowski
Jan 20, 2010·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Jin KimKwang Gill Lee
Sep 10, 2005·Journal of Biotechnology·Kyoung-Hwa KimChong-Pyoung Chung
Dec 5, 2014·Biotechnology and Applied Biochemistry·Mazaher GholipourmalekabadiHossein Ghanbarian
Mar 17, 2015·Advanced Healthcare Materials·Gang LiDavid L Kaplan
Jul 8, 2009·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Matthias W LaschkeMichael D Menger

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