Angiogenic factors in placentas from pregnancies complicated by fetal growth restriction (review)

Molecular Medicine Reports
Victor GourvasStavros Sifakis

Abstract

The placenta is the organ that is responsible for providing the developing fetus with all the nutrients necessary for its growth and is also responsible for removing fetal waste. Placentation is a crucial process that includes angiogenesis. Angiogenesis involves not only the fetal circulation, but also placental and endometrial vascular changes. In this study, we review the literature regarding any impairment in the angiogenic process in placentas from pregnancies complicated by fetal growth restriction (FGR). Angiogenesis is regulated by a list of factors, also known as growth factors, such as the vascular endothelial growth factor (VEGF), the placental growth factor (PlGF) and the basic fibroblastic growth factor (bFGF), as well as the partial pressure of oxygen in the fetoplacental vessels. Other factors, such as transcriptional factors, also play a pivotal role, controlling the above-mentioned growth factors. Alterations in these pathways have been described in cases of growth-restricted fetuses. In this review, we provide an insight into these processes and identify the most crucial factors involved.

Citations

Feb 26, 2016·Canadian Journal of Kidney Health and Disease·Ayub AkbariSwapnil Hiremath
Jun 19, 2014·International Journal of Molecular Sciences·Hong MaDi Liu
Jul 22, 2014·Reproduction in Domestic Animals = Zuchthygiene·B ZhangD Wu
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Mar 10, 2016·Stem Cells Translational Medicine·Chiara MandòIrene Cetin
Nov 23, 2019·Cells·Valentina Karin-KujundzicLjiljana Serman
Mar 14, 2018·Molecular Medicine Reports·Stavros SifakisNikos Papantoniou
Jan 23, 2013·The Journal of Clinical Endocrinology and Metabolism·Clare L WhiteheadStephen Tong
May 14, 2020·Disease Markers·Puspendra P SinghPraveen K Bharti
Jan 10, 2019·Mediators of Inflammation·Nikolaos AntonakopoulosNikolaos Vrachnis
Aug 14, 2020·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Turab JanbakhishovErdener Özer
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