Angiogenic, lymphangiogenic and adipogenic effects of HIV-1 matrix protein p17

Pathogens and Disease
Daniele BastaAlfredo Garzino-Demo

Abstract

Lymphangiogenesis and concurrent angiogenesis are essential in supporting proliferation and survival of AIDS-related lymphomas, which are often metastatic. In vitro studies suggest a candidate angiogienic and lymphangiogenic factor encoded by HIV: the matrix protein p17. p17 accumulates in lymph nodes of patients even when they are undergoing highly active antiretroviral therapy. p17 has been found to affect immune cells, and recent data showed that a variant p17, called S75X, induces cell growth by triggering MAPK/ERK and PI3K/AKT pathways. We tested the in vivo angiogenic activity of p17 by injecting it in Matrigel plugs in nude mice. Plugs were retrieved 7 days after injection, and assessed macroscopically, and by light and confocal microscopy. Our data revealed that both reference and S75X variant p17 promote angiogenesis and lymphangiogenesis in vivo. Our results suggest that the induction of angiogenesis and lymphangiogenesis by HIV-1 p17 may generate a favorable microenvironment that could trigger tumor growth and maintenance. Moreover, the presence of adipocytes infiltration observed at the histological level suggests a possible interplay between angiogenesis, lymphangiogenesis and adipogenesis. These findings offer new...Continue Reading

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Citations

Nov 19, 2015·Proceedings of the National Academy of Sciences of the United States of America·Riccardo DolcettiArnaldo Caruso
Jul 1, 2015·Pathogens and Disease·Virginia Carroll, Alfredo Garzino-Demo
Nov 4, 2016·Proceedings of the National Academy of Sciences of the United States of America·Virginia A CarrollAlfredo Garzino-Demo
Jun 9, 2017·Journal of Virology·Pietro MazzucaFrancesca Caccuri
Oct 13, 2017·Infectious Agents and Cancer·Francesca CaccuriStefania Marsico
Oct 8, 2019·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Karen C PattersonMaximiliano G Gutierrez
Aug 2, 2019·International Journal of Molecular Sciences·Thajasvarie NaickerJagidesa Moodley
Jul 18, 2021·The Journal of Biological Chemistry·Antonella BugattiArnaldo Caruso

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