Angiogenic markers in pregnancies conceived through in vitro fertilization

American Journal of Obstetrics and Gynecology
Malinda S LeeLouise E Wilkins-Haug

Abstract

Pregnancies that have been conceived through in vitro fertilization (IVF) have been associated with higher rates of preeclampsia and other complications that are associated with placental dysfunction. We evaluated whether IVF pregnancies, when compared with those conceived spontaneously, would be associated with alterations in serum angiogenic markers. This was a retrospective cohort study from 3 US academic institutions (2006-2008). Women with singleton pregnancies who conceived via IVF or spontaneously were included. Placental growth factor (PlGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) were measured at 4 time points throughout gestation. Pregnancy outcomes that included diagnosis of preeclampsia or other obstetric complications were ascertained from the medical record. The relationship among IVF status, PlGF, and sFlt-1 were modeled over gestation and stratified by clinical pregnancy outcome. Of the included 2392 singleton pregnancies, 4.5% (108 pregnancies) were conceived though IVF. IVF pregnancies were significantly more likely to be complicated by preeclampsia (15.7% vs 7.7%). IVF pregnancies had significantly higher levels of sFlt-1 at 18, 26, and 35 weeks of gestation (P = .04, P = .004, P < .0001, respectively...Continue Reading

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Citations

Sep 28, 2015·American Journal of Obstetrics and Gynecology·Dev MaulikShui Qing Ye
May 24, 2016·Journal de gynécologie, obstétrique et biologie de la reproduction·S VieillefosseE Lecarpentier
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Dec 20, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Reza Omani-SamaniPayam Amini
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Jun 9, 2019·Placenta·Alexandra CôtéAmélie Boutin
Aug 8, 2021·Journal of Clinical Medicine·Natalie K BinderNatalie J Hannan

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