Angiogenic peptide hydrogels for treatment of traumatic brain injury

Bioactive Materials
Xiaotang MaJames Haorah

Abstract

Traumatic brain injury (TBI) impacts over 3.17 million Americans. Management of hemorrhage and coagulation caused by vascular disruption after TBI is critical for the recovery of patients. Cerebrovascular pathologies play an important role in the underlying mechanisms of TBI. The objective of this study is to evaluate a novel regenerative medicine for the injured tissue after brain injury. We utilized a recently described synthetic growth factor with angiogenic potential to facilitate vascular growth in situ at the injury site. Previous work has shown how this injectable self-assembling peptide-based hydrogel (SAPH) creates a regenerative microenvironment for neovascularization at the injury site. Supramolecular assembly allows for thixotropy; the injectable drug delivery system provides sustained in vivo efficacy. In this study, a moderate blunt injury model was used to cause physical vascular damage and hemorrhage. The angiogenic SAPH was then applied directly on the injured rat brain. At day 7 post-TBI, significantly more blood vessels were observed than the sham and injury control group, as well as activation of VEGF-receptor 2, demonstrating the robust angiogenic response elicited by the angiogenic SAPH. Vascular markers v...Continue Reading

Citations

Jun 19, 2020·International Journal of Molecular Sciences·Raffaele Pugliese, Fabrizio Gelain
Oct 9, 2020·Future Medicinal Chemistry·Bikram KhadkaJong-Sup Bae
Dec 29, 2020·International Journal of Nanomedicine·Chaoshan HanJunjie Yang
Feb 25, 2021·Research : a Science Partner Journal·Rani MataChangyou Gao
Mar 11, 2021·Acta Biomaterialia·Zain SiddiquiVivek A Kumar

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