PMID: 9663610Jul 15, 1998Paper

Angiogenic potential of malignant and non-malignant human breast tissues in an in vivo angiogenesis model

International Journal of Cancer. Journal International Du Cancer
H C LichtenbeldH F Hillen

Abstract

Tumors need to acquire an angiogenic phenotype for outgrowth and metastasis formation. Limited information on the angiogenic potential of specific tissues, especially human breast tissues is available. Here we describe an in vivo model, using the dorsal skin fold chamber in immunodeficient nude mice, where various tissues of human breast origin were xenografted and evaluated for their angiogenesis-inducing potential. We found that angiogenesis was abundantly induced by all breast carcinoma tissue samples. Similar angiogenesis was induced by tissue samples from breasts with hyperplasia and apocrine metaplasia. Histologically normal tissues adjacent to the tumor induced angiogenesis in 66% of the cases. Angiogenesis was not induced by control tissues from normal healthy breasts, obtained after cosmetic breast reduction. Angiogenesis induction parallelled VEGF production by the tumor cells. The tissue induced neovascularization, found both around and in the human tissue, was functional since a tail vein injection of albumin-FITC revealed positive tumor microcirculation within 5 min, while the tumor tissue still consisted of vital human epithelial cells after 14 days.

References

Jan 3, 1990·Journal of the National Cancer Institute·J Folkman
Jan 1, 1984·Cancer Metastasis Reviews·F E Sharkey, J Fogh
Mar 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G GaspariniF Pozza
Jul 5, 1995·Journal of the National Cancer Institute·K AxelssonB H Mayall
Nov 1, 1995·British Journal of Cancer·R R MehtaT K Das Gupta
Jan 1, 1995·Breast Cancer Research and Treatment·M BarbareschiP Dalla Palma
Dec 1, 1996·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·H C LichtenbeldR K Jain
Nov 14, 1997·Nature Medicine·R K JainF Yuan

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Citations

Jan 15, 2008·Breast Cancer Research : BCR·Stephen B FoxAdrian L Harris
Nov 12, 2013·Ultrasound in Medicine & Biology·Xiao-Li CaoJie Xue
Jun 22, 2012·Burns : Journal of the International Society for Burn Injuries·Stefanie MichaelPeter M Vogt
Aug 30, 2011·Cancer Treatment Reviews·Javier Cortes, Henri Roché
Nov 10, 2010·International Journal of Experimental Pathology·Mackenzie J SmithBrenda L Coomber
Jan 23, 2002·Japanese Journal of Cancer Research : Gann·Nobuko Shindo-OkadaYasuhiro Nagamachi
Feb 27, 2001·Japanese Journal of Cancer Research : Gann·N Shindo-OkadaY Nagamachi
Jul 16, 2003·Laboratory Investigation; a Journal of Technical Methods and Pathology·Sue C HeffelfingerDavid Warshawsky
Jan 22, 2008·Journal of Mammary Gland Biology and Neoplasia·Carmen ClappGonzalo Martínez de la Escalera
Apr 26, 2014·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Man ChenXiao-chun Fei
May 24, 2008·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Jing DuCai-Xia Zhu
Jul 6, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·M S PepperM L Iruela-Arispe
Feb 13, 2001·Microscopy Research and Technique·V DjonovA Ziemiecki
Jan 13, 2006·British Journal of Cancer·L BingleN J Brown
May 24, 2008·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Jing DuCai-Xia Zhu
Feb 15, 2013·Thrombosis and Haemostasis·Josef EhlingFabian Kiessling
Apr 16, 2002·British Journal of Cancer·N B TeoC Holcombe
Nov 21, 2020·Scientific Reports·Tae Joon Kwak, Esak Lee
Jul 20, 1999·Molecular and Cellular Endocrinology·V GoffinP A Kelly
Jun 16, 2021·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Maggie F TawfikAsmaa F Khafaga

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