Angiogenic Properties of Menstrual Stem Cells Are Impaired in Women with a History of Preeclampsia

Stem Cells International
Manuel Varas-GodoySebastian E Illanes

Abstract

Preeclampsia is a pregnancy-specific disorder defined by the new onset of hypertension and proteinuria after 20 weeks of gestation. Although its precise etiology is still unknown, there is evidence suggesting that it may be a consequence of impaired decidual and stromal cell function. Recently, a stem cell population derived from endometrial tissue and isolated from menstrual effluent called menstrual stem cells (MenSCs) has been identified. MenSCs exhibit important angiogenic and inflammatory properties that may contribute to both normal and pathological complications of implantation and placentation, including preeclampsia. We hypothesized that the angiogenic and inflammatory activity of MenSCs is altered in women who have a past history of preeclampsia and that this phenotype persists postpartum. The primary outcome measures were stromal progenitor cell formation, in vitro induction of endothelial tube formation, and release of proinflammatory cytokines. MenSCs obtained from women with a previous normal or preeclamptic pregnancy displayed similar phenotypic characteristics, tri-differentiation capacity, and proliferation. MenSCs derived from women who had preeclampsia on their previous pregnancy had reduced angiogenic capaci...Continue Reading

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Methods Mentioned

BETA
flow cytometry
fluorescence-activated cell sorting
Assay
protein solution array
Protein Assay
ELISA

Software Mentioned

GraphPad
FlowJo
ImageJ Angiogenesis Analyzer
Milliplex Analyst
GraphPad Prism

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