Angiogram based fractional flow reserve in patients with dual/triple vessel coronary artery disease

International Journal of Cardiology
H OmoriH Matsuo

Abstract

To assess the performance of angiography derived Fractional Flow Reserve (FFRangio) in multivessel disease (MVD) patients undergoing angiography. FFR is the reference standard for physiologic assessment of coronary stenosis and guidance of revascularization, especially in patients with MVD, yet it remains grossly underutilized. The non-wire based FFRangio performs well in non-MVD patients, but its accuracy in MVD is unknown. A prospective clinical study was conducted at Gifu Heart Centre, Japan. Patients underwent physiologic assessment of all relevant coronary lesions using wire-based FFR (wbFFR) and FFRangio. Primary outcome was diagnostic performance (sensitivity, specificity, accuracy) for FFRangio with wbFFR as reference. Other outcomes were the correlation between wbFFR/FFRangio, time required for wbFFR/FFRangio measurements, and the effect of wbFFR/FFRangio on the reclassification of coronary disease severity. Fifty patients (118 lesions in total) were included. Mean age was 72 ± 9 years, 72% were male, 36% had triple vessel disease and the average SYNTAX score was 13. The mean measurement of wbFFR and FFRangio were 0.83 ± 0.12 and 0.81 ± 0.11, respectively. Accuracy, sensitivity and specificity for FFRangio were 92.3% (...Continue Reading

Citations

Mar 12, 2020·Journal of the American Heart Association·Paul D MorrisJulian P Gunn
Jul 31, 2021·Trends in Cardiovascular Medicine·Dimitrios Terentes-PrintziosCharalambos Vlachopoulos
Aug 14, 2021·Journal of cardiology·Tatsunori TakahashiYuhei Kobayashi
Jan 4, 2022·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Ilya O StarodumovFelix A Blyakhman

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