Angiographic assessment of human coronary artery endothelial function by measurement of endothelium-dependent vasodilation.

European Heart Journal
C BossallerP R Lichtlen

Abstract

In isolated atherosclerotic human coronary arteries endothelium-dependent vascular relaxation is abolished with acetylcholine whereas another EDRF-dependent vasodilator, substance P, still produces significant relaxation. To study further these in vitro findings, graded doses of acetylcholine and substance P, which produced no systemic effects, were infused into the left anterior descending artery of patients with angiographically moderate coronary artery disease. The effects of acetylcholine and substance P on LAD diameter were analysed by quantitative angiography. Generally, acetylcholine caused no relaxation but concentration-dependent contraction from 1.67 +/- 0.06 mm to 1.45 +/- 0.09 mm (P less than 0.01), whereas substance P dilated the arteries to 1.89 +/- 0.10 mm (P less than 0.01). In contrast, both drugs caused a marked increase in great cardiac vein oxygen saturation, indicating an increase of coronary flow. The results suggest that the failure of the atherosclerotic epicardial human coronary artery to vasodilate in response to acetylcholine represents a muscarinic endothelial defect. The preserved vasodilation with substance P in the presence of a refractoriness to acetylcholine suggests that atherosclerotic human c...Continue Reading

Citations

Jan 1, 1990·International Journal of Cardiac Imaging·S JostI Knop
Jan 1, 1997·Progress in Cardiovascular Diseases·G R De Meyer, A G Herman
May 28, 2002·Circulation Journal : Official Journal of the Japanese Circulation Society·Takehiko MiyashitaIsao Kubota

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