Angiographic Cystoid Macular Edema and Outcomes in the Comparison of Age-Related Macular Degeneration Treatments Trials

Ophthalmology
Neepa ShahComparison of Age-related Macular Degeneration Treatments Trials Research Group

Abstract

To describe morphologic and visual outcomes in eyes with angiographic cystoid macular edema (CME) treated with ranibizumab or bevacizumab for neovascular age-related macular degeneration (nAMD). Prospective cohort study within a randomized clinical trial. A total of 1185 CATT study subjects. Baseline fluorescein angiography (FA) images of all CATT study eyes were evaluated for CME. Grading of other characteristics on optical coherence tomography (OCT) and photographic images at baseline and during 2-year follow-up was completed by readers at the CATT Reading Centers. Three groups were created on the basis of baseline CME and intraretinal fluid (IRF) status: (1) CME, (2) IRF without CME, (3) neither CME nor IRF. Visual acuity (VA) and total central retinal thickness (CRT) on OCT at baseline, year 1, and year 2. Among 1131 participants with images of sufficient quality for determining CME and IRF at baseline, 92 (8.1%) had CME, 766 (67.7%) had IRF without CME, and 273 (24.1%) had neither. At baseline, eyes with CME had worse mean VA (letters) than eyes with IRF without CME and eyes with neither CME nor IRF (52 vs. 60 vs. 66 letters, P < 0.001); higher mean total CRT (μm) on OCT (514 vs. 472 vs. 404, P < 0.001); and greater hemorr...Continue Reading

References

May 1, 1992·Optometry and Vision Science : Official Publication of the American Academy of Optometry·T D Williams, J M Wilkinson
Mar 1, 1996·Survey of Ophthalmology·A Mendivil
Aug 10, 2006·Japanese Journal of Ophthalmology·Kazuki Hotta, Junko Hotta
Mar 11, 2008·Retina·Lawrence A YannuzziBeatriz S Takahashi
Apr 30, 2011·The New England Journal of Medicine·UNKNOWN CATT Research GroupGlenn J Jaffe
May 5, 2012·Ophthalmology·UNKNOWN Comparison of Age-related Macular Degeneration Treatments Trials (CATT) Research GroupFrederick L Ferris
Oct 11, 2012·Ophthalmology·Gui-shuang YingUNKNOWN Comparison of Age-related Macular Degeneration Treatments Trials Research Group
May 7, 2013·Ophthalmology·Glenn J JaffeUNKNOWN Comparison of Age-related Macular Degeneration Treatments Trials Research Group

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Citations

Jul 2, 2016·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·B BookA Lommatzsch
Mar 6, 2019·The Cochrane Database of Systematic Reviews·Sharon D SolomonBarbara S Hawkins
Jun 18, 2017·Ophthalmology Retina·Ebenezer DanielUNKNOWN Comparison of Age-related Macular Degeneration Treatments Trials (CATT) Research Group

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