Angiographic predictors of 2-year stent thrombosis in patients receiving drug-eluting stents: Insights from the ADAPT-DES study

Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions
Philippe GénéreuxGregg W Stone

Abstract

We sought to identify angiographic predictors of 2-year stent thrombosis (ST) in the ADAPT-DES study. A strong relationship between platelet reactivity and ST after implantation of drug-eluting stents (DES) was recently confirmed in the prospective, multicenter ADAPT-DES study. In a pre-specified analysis of patients enrolled in ADAPT-DES, an independent angiographic core laboratory performed detailed angiographic analyses for all cases of ST. Patients with Academic Research Consortium definite/probable target-lesion ST were matched with controls in a 1:2 ratio, and multivariable Cox regression models identified angiographic predictors of 2-year ST. Among 8,582 patients who had successful percutaneous coronary intervention (PCI) and were included in the ADAPT-DES study, 92 (1.1%) patients had ST at 2-year follow-up. Target lesion-related ST was identified in 77 patients (82 lesions) who were clinically matched with 153 patients (196 lesions) without ST. Patients with ST were more likely to have longer target lesions, thrombus, moderate/severe calcification, American College of Cardiology/American Heart Association (ACC/AHA) type C lesions, and saphenous vein grafts. After adjustment for clinical covariates the angiographic vari...Continue Reading

References

May 5, 2005·JAMA : the Journal of the American Medical Association·Ioannis IakovouAntonio Colombo
Jul 25, 2006·The American Journal of Cardiology·Duk-Woo ParkSeung-Jung Park
Feb 14, 2007·The New England Journal of Medicine·Laura MauriDonald E Cutlip
May 2, 2007·Circulation·Donald E CutlipUNKNOWN Academic Research Consortium
Aug 7, 2007·Journal of the American College of Cardiology·Jacques MachecourtUNKNOWN EVASTENT Investigators
Nov 6, 2007·The New England Journal of Medicine·Stephen D WiviottUNKNOWN TRITON-TIMI 38 Investigators
Mar 8, 2008·Journal of the American College of Cardiology·José M de la Torre-HernándezUNKNOWN ESTROFA Study Group
Jul 1, 2008·American Heart Journal·Gregory J MishkelMarc E Shelton
Apr 18, 2009·Journal of the American College of Cardiology·Jochem W van WerkumJurriën M ten Berg
Sep 1, 2009·The New England Journal of Medicine·Lars WallentinMona Thorsén
Jan 19, 2010·Lancet·Christopher P CannonUNKNOWN PLATelet inhibition and patient Outcomes Investigators
Oct 16, 2010·Journal of the American College of Cardiology·David R HolmesDavid J Moliterno
Oct 27, 2011·Circulation. Cardiovascular Interventions·Tullio PalmeriniGregg W Stone
Mar 23, 2012·Circulation·Marco ValgimigliUNKNOWN Prolonging Dual Antiplatelet Treatment After Grading Stent-Induced Intimal Hyperplasia Study (PRODIGY) Investigators
Jan 11, 2014·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Mayank YadavGregg W Stone
Feb 18, 2014·JACC. Cardiovascular Interventions·Jae-Sik JangDong-Soo Kim
Nov 18, 2014·The New England Journal of Medicine·Laura MauriUNKNOWN DAPT Study Investigators
Sep 30, 2015·Circulation. Cardiovascular Interventions·Bruce R BrodieGregg W Stone

❮ Previous
Next ❯

Citations

Apr 17, 2016·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Philippe GénéreuxJeff W Chambers
Sep 15, 2016·Journal of Interventional Cardiology·Carlo BriguoriAmelia Focaccio
Mar 16, 2017·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Enrico RomagnoliFrancesco Prati
Jan 25, 2017·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Vanesa F Nuñez López, Mauricio G Cohen
Dec 27, 2017·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Mohamed Y BechiriNicolas Amabile
Apr 15, 2018·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·H LuK T Koch
Apr 3, 2020·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Rosaly A BuitenClemens von Birgelen
Mar 22, 2019·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·R RozemeijerM Voskuil
Dec 7, 2018·Nature Reviews. Cardiology·Tommaso GoriThomas Münzel

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.