Angiographic Structural Differentiation between Native Arteriogenesis and Therapeutic Synangiosis in Intracranial Arterial Steno-Occlusive Disease

AJNR. American Journal of Neuroradiology
Y C OoiNestor R Gonzalez

Abstract

Encephaloduroarteriosynangiosis has been shown to generate collateral vessels from the extracranial-to-intracranial circulation in patients with Moyamoya disease and intracranial arterial steno-occlusive disease. The mechanisms involved are not well-understood. We hypothesized that angiogenesis is the leading mechanism forming collaterals after encephaloduroarteriosynangiosis because there are no pre-existing connections. Angiogenesis-generated collaterals should exhibit higher architectural complexity compared with innate collaterals. Pre- and postoperative digital subtraction angiograms were analyzed in patients enrolled in a prospective trial of encephaloduroarteriosynangiosis surgery. Branching angioscore, tortuosity index, and local connected fractal dimension were compared between innate and postoperative collaterals. One hundred one angiograms (50 preoperative, 51 postoperative) were analyzed from 44 patients (22 with intracranial atherosclerosis and 22 with Moyamoya disease). There was a significantly higher median branching angioscore (13 versus 4, P < .001) and a lower median tortuosity index (1.08 versus 1.76, P < .001) in the encephaloduroarteriosynangiosis collaterals compared with innate collaterals. Higher mean l...Continue Reading

Associated Clinical Trials

References

May 1, 1996·Catheterization and Cardiovascular Diagnosis·M JakobO M Hess
Sep 5, 2003·Seminars in Ultrasound, CT, and MR·Douglas Green, Dennis Parker
Mar 28, 2006·Journal of Cellular and Molecular Medicine·M HeilW Schaper
Jul 29, 2006·Clinical Neurology and Neurosurgery·Dal-Soo KimChun Kun Park
Feb 16, 2008·Neurosurgical Focus·Anand VeeravaguGary K Steinberg
Jun 7, 2008·Stroke; a Journal of Cerebral Circulation·Philip B GorelickDilip K Pandey
Jun 12, 2008·Arquivos de neuro-psiquiatria·Zeferino DemartiniMárcio Luiz Tostes Dos Santos
Mar 26, 2011·Annals of Neurology·David S LiebeskindUNKNOWN Warfarin-Aspirin Symptomatic Intracranial Disease (WASID) Investigators
Nov 22, 2011·Microvascular Research·J LuoP Grammas
Aug 30, 2012·Nature Methods·Caroline A SchneiderKevin W Eliceiri
Oct 26, 2012·Neurosurgical Review·Nestor R GonzalezJeffrey Saver

❮ Previous
Next ❯

Citations

May 20, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Hua ZhangJames E Faber
Aug 24, 2019·Scientific Reports·Ion AndronacheDaniel Peptenatu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Related Papers

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
Makiko TanakaKazuo Kitagawa
JAMA Ophthalmology
Diana KatsmanSriniVas Sadda
Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery
Shunji Mugikura, Shoki Takahashi
© 2022 Meta ULC. All rights reserved