Angiokine Wisp-1 is increased in myocardial infarction and regulates cardiac endothelial signaling

JCI Insight
Lillianne H WrightDonald R Menick

Abstract

Myocardial infarctions (MIs) cause the loss of myocytes due to lack of sufficient oxygenation and latent revascularization. Although the administration of histone deacetylase (HDAC) inhibitors reduces the size of infarctions and improves cardiac physiology in small-animal models of MI injury, the cellular targets of the HDACs, which the drugs inhibit, are largely unspecified. Here, we show that WNT-inducible secreted protein-1 (Wisp-1), a matricellular protein that promotes angiogenesis in cancers as well as cell survival in isolated cardiac myocytes and neurons, is a target of HDACs. Further, Wisp-1 transcription is regulated by HDACs and can be modified by the HDAC inhibitor, suberanilohydroxamic acid (SAHA/vorinostat), after MI injury. We observe that, at 7 days after MI, Wisp-1 is elevated 3-fold greater in the border zone of infarction in mice that experience an MI injury and are injected daily with SAHA, relative to MI alone. Additionally, human coronary artery endothelial cells (HCAECs) produce WISP-1 and are responsive to autocrine WISP-1-mediated signaling, which functionally promotes their proangiogenic behavior. Altering endogenous expression of WISP-1 in HCAECs directly impacts their network density in vitro. Therap...Continue Reading

References

Aug 1, 1996·Journal of Cellular Biochemistry·J R Davie
Aug 1, 1998·The Journal of Biological Chemistry·K B ChoiA Karsan
Sep 12, 1998·Science·J M Adams, S Cory
Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·D PennicaA J Levine
Jul 27, 2001·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·N R BertosX J Yang
Oct 13, 2001·The Journal of Biological Chemistry·L DesnoyersD Pennica
May 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Neru MunshiRamesh K Ganju
Feb 8, 2003·Circulation Research·Bernardo Nadal-GinardPiero Anversa
Sep 17, 2003·The Journal of Pharmacology and Experimental Therapeutics·Erding HuMichael Jaye
Dec 6, 2003·Proceedings of the National Academy of Sciences of the United States of America·David A HildemanPhilippa Marrack
Apr 3, 2004·Molecular and Cellular Biology·Laurence LévyChristine Neuveut
Jun 24, 2004·American Journal of Physiology. Heart and Circulatory Physiology·C BerthonnecheP Janiak
Jul 5, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Erin A BoothBenedict R Lucchesi
Jan 18, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Rong Xue WuOliver Ritter
Apr 3, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Tsung-Ming LeeNen-Chung Chang
Jul 10, 2007·American Journal of Physiology. Heart and Circulatory Physiology·J T ColstonB Chandrasekar
Feb 5, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Wenfu TanJ Silvio Gutkind
Jul 9, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Anne GrangerPeter J Gruber
Sep 9, 2008·The International Journal of Biochemistry & Cell Biology·Chih-Chiun Chen, Lester F Lau
Feb 25, 2009·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Hongying WangWallace K MacNaughton
Apr 20, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Brad A BryanPatricia A D'Amore
Nov 17, 2010·Proceedings of the National Academy of Sciences of the United States of America·Wei HeVictor J Dzau
Mar 4, 2011·Proceedings of the National Academy of Sciences of the United States of America·Dian J CaoJoseph A Hill
May 14, 2011·The Journal of Obstetrics and Gynaecology Research·Qionglan TangGengbiao Chen
Jun 16, 2011·Journal of Visualized Experiments : JoVE·Jitka A I Virag, Robert M Lust
Sep 1, 2011·Handbook of Experimental Pharmacology·Timothy A McKinsey
Apr 27, 2012·Physiological Reviews·Nikolaos G Frangogiannis
Jul 31, 2012·Therapeutic Delivery·Hunghao Chu, Yadong Wang
Aug 9, 2012·Antioxidants & Redox Signaling·Clement CochainJean-Sébastien Silvestre
Nov 16, 2012·Current Neurovascular Research·Shaohui WangKenneth Maiese
Dec 12, 2012·Atherosclerosis·Fisnik JashariMichael Y Henein
Mar 7, 2014·Cell & Bioscience·Chenxi GaoJing Hu

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Citations

Sep 9, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Bo WangWujun Xue
Nov 28, 2020·Archives of Pharmacal Research·Pusoon Chun
Jan 21, 2021·Journal of the American Heart Association·Vincent F M Segers, Gilles W De Keulenaer
Jan 28, 2021·Medicina·Małgorzata Mirr, Maciej Owecki
Dec 8, 2020·Frontiers in Cell and Developmental Biology·Xiaona ChenHong Li
Mar 29, 2020·Current Neurovascular Research·Kenneth Maiese
Oct 17, 2020·Cardiovascular Research·Xuekun WuKai C Wollert
Apr 8, 2021·Circulation Research·Ryan M BurkeEric M Small

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Methods Mentioned

BETA
protein treatment
acetylation
ChIP
transgenic
PCR
electrophoresis
transfection

Software Mentioned

ImageJ
Fiji
Image J

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