Angiomatoid Fibrous Histiocytoma With Paraneoplastic Platelet Storage Pool Deficiency

Pediatrics
Lerraughn M MorganJennifer D Elster

Abstract

Angiomatoid fibrous histiocytoma is a rare soft tissue tumor usually discovered in young individuals. This tumor is often mistaken for a hematoma and typically misdiagnosed. It is commonly found in the extremities and may be associated with a site of recent or previous trauma. Characteristic histology includes nodules of histiocytoid spindle cells with pseudoangiomatoid spaces, fibrous pseudocapsules, and lymphoid cuffing. We describe the case of an 8-year-old girl who presented after incision and drainage of a superficial thigh lesion and experienced subsequent chronic bleeding of her wound. Her initial presentation was concerning for an underlying bleeding disorder, and laboratory analysis uncovered a paraneoplastic platelet function disorder that resolved with therapy of the primary tumor.

References

Jul 28, 2001·Archives of Pathology & Laboratory Medicine·D A BiddleA N Nguyen
Jan 20, 2006·Journal of Thrombosis and Haemostasis : JTH·C P M HaywardUNKNOWN Platelet Physiology Subcommittee of the Scientific and Standardization Committee of the International Society on Thrombosis
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Jan 22, 2010·The American Journal of Surgical Pathology·David Chas ManghamWim Paul Cool
Apr 4, 2014·Cancer Metastasis Reviews·David G MenterKenneth V Honn

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Citations

Oct 6, 2021·Arkhiv patologii·A S FedorovaD M Konovalov
Aug 21, 2019·Pediatric Neurosurgery·Michael D WhiteStephanie Greene

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