Abstract
The vascular system of human renal clear cell carcinoma was studied using light microscopy of silicon rubber-injected specimens and scanning electron microscopy of conventionally prepared tissue and vascular corrosion casts. The system was found to exhibit the following features: (1) a well developed superficial vascular coat showing different pattern on the anterior and on the posterior side of the tumour, (2) an internal vascular network composed of altered and displaced preexisting vessels, numerous newly formed ones and those recruited from adjacent structures, (3) quantitative prevalence of dilated veins and distended capillaries, (4) a remarkable proliferative reaction of stellate veins, (5) characteristic features of the intratumour vasculature in the form of avascular nodules surrounded by basket-like capillary plexuses and separated by well vascularized "septa", (6) a relatively less dense vascularization of central tumour areas, frequently exhibiting necrotic foci, and the highest density of vessels in areas close to the superficial vascular coat, and (7) morphological evidence for a continuous remodelling of the tumour vasculature. The observed patterns of the vascular system seem to provide a pathway for further tum...Continue Reading
References
Mar 1, 1978·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P Falk
May 1, 1978·Cancer Letters·B A WarrenR Feldman
Feb 1, 1975·The American Journal of Anatomy·C J Peine, F N Low
Apr 1, 1986·Clinical & Experimental Metastasis·R F NicosiaJ Leighton
Apr 1, 1987·The Journal of Pathology·W D ThompsonJ G Simpson
Jan 1, 1986·Virchows Archiv. A, Pathological Anatomy and Histopathology·D A TerrerosF E Cuppage
May 1, 1986·Pathology, Research and Practice·W ThoenesH J Rumpelt
Oct 10, 1966·Virchows Archiv Für Pathologische Anatomie Und Physiologie Und Für Klinische Medizin·J L EricssonS Orrenius
Sep 1, 1972·The Journal of Urology·E R Fisher, B Horvat
Feb 1, 1971·Archivum Histologicum Japonicum = Nihon Soshikigaku Kiroku·T Murakami
Jan 1, 1982·Journal of Cancer Research and Clinical Oncology·P Shubik
Feb 1, 1982·European Journal of Cancer & Clinical Oncology·P Falk
Jan 22, 1981·Nature·I Vlodavsky, D Gospodarowicz
Apr 30, 1960·Nature·C OBERLINGF HAGUENAU
Citations
Nov 1, 1990·Cancer Metastasis Reviews·J Denekamp
Oct 19, 2007·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·P SladkeviciusL Valentin
Mar 1, 2019·Nature Reviews. Clinical Oncology·Elizabeth A KuczynskiAndrew R Reynolds
Dec 22, 1999·British Journal of Cancer·K GrosiosM C Bibby
Nov 2, 1999·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·C J Drake, C D Little
Jan 19, 2006·Technology in Cancer Research & Treatment·H W SalmonD W Siemann
Jan 25, 2014·Microscopy Research and Technique·ViníCius Faccin BampiJefferson Luis Braga Da Silva
Jan 1, 1991·Virchows Archiv. A, Pathological Anatomy and Histopathology·T KaidohY Uehara
Aug 6, 2000·Developmental Biology·C J DrakeC D Little
May 11, 2005·Journal of Theoretical Biology·Natalia L Komarova, Vladimir Mironov
Jan 5, 2002·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·B Romanowska-DixonA Miodonski
Jan 1, 1991·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J Denekamp, S Hill