PMID: 9536990Apr 16, 1998Paper

Angiopoietin-2, a new molecular actor involved in vascular tree morphogenesis

Bulletin du cancer
B Vandenbunder

Abstract

Angiopoietin-2 is a new member of the family of the ligands of Tek (Tie2), a transmembrane receptor with tyrosine kinase activity which is specifically expressed in endothelial cells during angiogenesis. Several lines of evidence indicate that angiopoietin-1 is involved in pericyte recruitment by endothelial cells and in the maintenance of cell-cell and cell matrix association in mature capillaries. Angiopoietin-2 behaves as an antagonist of angiopoietin-1. It is suggested that it looses capillary structure and renders endothelial cells to become responsive to angiogenic stimuli.

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