Angiopoietin-2 in the perinatal period and the role of intrauterine growth restriction

Acta Obstetricia Et Gynecologica Scandinavica
Ariadne Malamitsi-PuchnerDimitrios Hassiakos

Abstract

Angiopoietin-2, an angiogenic factor, causing destabilization and postnatal remodeling of blood vessels, is upregulated by hypoxia. We hypothesized that circulating Angiopoietin-2 levels might differ in intrauterine growth restricted and appropriate for gestational age fetuses and neonates, as the former have restricted growth and development and suffer from in utero hypoxia. This is a prospective, controlled study, including forty asymmetric, mainly due to hypertension or pre-eclampsia intrauterine growth restricted (0-9 customized centiles, corrected for gestational age, sex, maternal weight, height, ethnic group, and parity), and 20 appropriate for gestational age (42-82 customized centiles) full-term infants, as well as their mothers. Blood samples were drawn from mothers, from the doubly clamped umbilical cord (mixed arteriovenous blood, representing fetal state), and from neonates on days 1 (N1) and 4 (N4) of life (representing transition and stabilization to extrauterine life, respectively). Circulating angiopoietin-2 levels were measured by enzyme immunoassay and the statistical analysis involved t-test and Pearson correlation. Angiopoietin-2 levels were significantly higher in intrauterine growth restricted cases only ...Continue Reading

Citations

Feb 16, 2008·Mediators of Inflammation·Despina D BrianaAriadne Malamitsi-Puchner
May 16, 2012·Acta Obstetricia Et Gynecologica Scandinavica·Elina KeikkalaPiia Vuorela
Oct 31, 2006·Early Human Development·Ariadne Malamitsi-PuchnerDemetrios Hassiakos
Feb 27, 2016·Clinical Chemistry and Laboratory Medicine : CCLM·Young Bae HansenSteen Sørensen

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