Angiopoietin-like gene expression in the mouse uterus during implantation and in response to steroids.

Cell and Tissue Research
Charles A ScottBrent M Bany

Abstract

The purpose of this work was to determine if and where Angiopoietin-like genes are expressed in the mouse uterus during the implantation period of pregnancy and to determine if uterine expression of such genes is controlled by estrogen or progesterone. We found that all six known murine angiopoietin-like genes were expressed in the mouse uterus during implantation. The expression of four genes was controlled by either estrogen or progesterone. Only the levels of angiopoietin-like 4 (Angptl4) mRNA dramatically increased in implantation segments of the uterus during decidualization and was conceptus-independent. Due to this increased expression and the fact that angiopoietin-like 4 protein plays a role in lipid metabolism and angiogenesis in other tissues, only the expression of Angptl4 was further examined in the uterus and developing placenta. Angptl4 mRNA was localized to subpopulations of the endometrial stromal fibroblast and endothelial cell populations during decidualization. It was also localized to the ectoplacental cone, trophoblast giant cells and parietal endoderm of the conceptus at this time. By mid-pregnancy, Angptl4 mRNA was localized mainly to the mesometrial lymphoid aggregate region plus mesometrial endothelial...Continue Reading

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Citations

Mar 13, 2014·TheScientificWorldJournal·Naguib Salleh
Mar 16, 2013·Advanced Healthcare Materials·Xuetao ShiHongkai Wu
Jan 13, 2018·Molecular Human Reproduction·Camille L DuranKayla J Bayless
Sep 27, 2018·Reproduction, Fertility, and Development·Iside ScaravaggiStefan Bauersachs

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