Angiosarcoma in FNA smears: diagnostic accuracy, morphology, immunocytochemistry and differential diagnoses

Cytopathology : Official Journal of the British Society for Clinical Cytology
Z Pohar-Marinsek, J Lamovec

Abstract

The aim of our study was to analyse the diagnostic accuracy in recognizing angiosarcoma from fine needle aspiration (FNA) samples and to determine morphological features of angiosarcoma in cytology. FNA samples from 18 histologically confirmed angiosarcomas obtained between 1985 and 2009 were included in the study. Original cytological diagnoses were retrieved, smears reviewed and morphological features analysed: cellularity, smear pattern, cell morphology, contents of background. Outcome of immunocytochemistry was noted and additional reactions performed if material was available. There were 13 primary angiosarcomas and five recurrent tumours; nine tumours were epithelioid. Twelve tumours were cytologically diagnosed as malignant, three as suspicious and three were judged unsatisfactory. Only two primary tumours were diagnosed as vascular. According to morphology, tumours were divided into those with predominantly epithelioid cells and those with predominantly spindle cells. Within these two groups were variations due to grade of tumour. Cytomorphology did not correlate well with histology in mixed and spindle cell types of angiosarcomas. Immunocytochemistry was applied in seven cases, specific vascular marker CD31 only twice ...Continue Reading

References

Jan 1, 1990·Gastrointestinal Radiology·Y HertzanuH Zirkin
Jan 1, 1983·The American Journal of Surgical Pathology·M J MerinoM Berman
Sep 1, 1994·American Journal of Clinical Pathology·S E MillsL M Weiss
Sep 5, 1998·American Journal of Clinical Pathology·B R De YoungP E Swanson
Jun 1, 1999·Acta Cytologica·K Liu, L J Layfield
Feb 19, 2000·Diagnostic Cytopathology·Z Vesoulis, C Cunliffe
Aug 15, 2000·American Journal of Clinical Pathology·L D BoucherK R Geisinger
Aug 31, 2000·Cancer·P E WakelyJ S Kneisl
Nov 2, 2001·The American Journal of Surgical Pathology·J K McKenneyA L Folpe
Jul 12, 2002·Diagnostic Cytopathology·Corrado MinimoOscar Lin
Jul 31, 2002·Acta Cytologica·Oscar LinInes Vieira de Castro
Jul 29, 2005·Archives of Pathology & Laboratory Medicine·Victor DelacruzParvin Ganjei
Nov 22, 2005·Diagnostic Cytopathology·Jean-Pierre GagnerGrace C H Yang
Dec 13, 2005·Acta Cytologica·Yasuhiko KiyozukaAiro Tsubura
Mar 8, 2008·Acta Cytologica·Neelaiah SiddarajuSumit Kumar Roy

❮ Previous
Next ❯

Citations

Jun 16, 2012·International Journal of Oral Science·Rei KarubeHiroki Bukawa
Dec 24, 2013·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·Gopisankar G BalajiBurad Deepak
Jun 24, 2011·Diagnostic Cytopathology·Charanjeet SinghStefan E Pambuccian
Feb 5, 2015·Seminars in Diagnostic Pathology·Leslie G Dodd, Johann Hertel
Jul 12, 2014·Korean Journal of Pathology·Min Jung Jung, Young Ok Kim
Apr 22, 2021·Diagnostic Cytopathology·Paul G NoditChristopher T Clark

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.