Angiostatins decrease in the kidney of newborn piglets after hypoxia-reoxygenation

European Journal of Pharmacology
Marwan EmaraPo-Yin Cheung

Abstract

Little is known about the expression of kidney angiostatin in the hypoxia and reoxygenation of neonates. In this study, we compared the effect of 21% and 100% reoxygenation on kidney levels of angiostatin and its related factors in newborn piglets subjected to hypoxia-reoxygenation. Newborn piglets were subjected to 2h hypoxia followed by 1h of reoxygenation with either 21% or 100% oxygen and observed for 4days. There were 3 isoforms (38, 43 and 50kDa) of angiostatins identified in the kidney tissue of newborn piglets with the 38kDa being the major isoform (~60%). The 38kDa, but not 43 and 50kDa, angiostatin isoform correlated significantly with the levels of total angiostatin and plasminogen (r=0.95 and r=0.58, respectively). On day 4 of recovery in 100% hypoxic-reoxygenated group, there were decreases in kidney tissue levels of plasminogen, total angiostatin, angiostatin (38 and 43kDa, but not 50kDa), whereas no significant changes were found in the 21% hypoxic-reoxygenated group when compared to the sham-operated piglets with no hypoxia-reoxygenation. Both 21% and 100% hypoxic-reoxygenated groups did not show significant changes in kidney tissue levels of 50kDa angiostatin, MMP-2, MMP-9 and HIF-1alpha. In comparison to 21% o...Continue Reading

References

Jan 13, 1998·Current Opinion in Cell Biology·K Gallagher, L G Smith
Mar 20, 1999·The Journal of Biological Chemistry·P StathakisP J Hogg
May 13, 1999·Proceedings of the National Academy of Sciences of the United States of America·R CaoY Cao
Oct 26, 1999·Biochemical and Biophysical Research Communications·N J MacDonaldB K Sim
May 8, 2002·Circulation·Toshiro MatsunagaWilliam M Chilian
Jul 13, 2002·International Journal of Cancer. Journal International Du Cancer·M Mercedes BindaR Daniel Bonfil
Mar 18, 2003·The Journal of Pediatrics·Máximo VentoJosé Viña
Oct 11, 2003·Biochemical and Biophysical Research Communications·Ya-Huey ChenLi-Wha Wu
Jan 14, 2004·Journal of Thrombosis and Haemostasis : JTH·J H Geiger, S E Cnudde
Feb 20, 2004·Pediatric Research·Christina G SchulzPo-Yin Cheung
Mar 23, 2004·Seminars in Thrombosis and Hemostasis·Yihai Cao, Lexun Xue
Apr 13, 2004·American Journal of Physiology. Renal Physiology·David P BasileWilliam M Chilian
Dec 25, 2004·The International Journal of Biochemistry & Cell Biology·Marc-André C DéryDarren E Richard
Feb 9, 2005·Paediatric Respiratory Reviews·Alison Hislop
Feb 16, 2005·Toxicology and Applied Pharmacology·Tiina M Asikainen, Carl W White
Jul 13, 2005·Proceedings of the National Academy of Sciences of the United States of America·Tiina M AsikainenCarl W White
Dec 3, 2005·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Diane BouïsGeke A P Hospers
Apr 22, 2006·Pediatric Research·Po-Yin CheungMarek W Radomski
Jul 4, 2006·American Journal of Ophthalmology·John T Flynn, Tailoi Chan-Ling
Aug 3, 2006·Pediatrics·Ola Didrik SaugstadMax Vento
Aug 28, 2007·Archives of Biochemistry and Biophysics·Marwan EmaraPo-Yin Cheung
Oct 15, 2008·Hypertension·Catherine YzydorczykAnne Monique Nuyt

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Jul 13, 2013·Annals of Human Genetics·Karen NuytemansJeffery M Vance

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