Angiotensin-(1-7) and low-dose angiotensin II infusion reverse salt-induced endothelial dysfunction via different mechanisms in rat middle cerebral arteries.

American Journal of Physiology. Heart and Circulatory Physiology
Matthew J DurandJulian H Lombard

Abstract

The goals of this study were to 1) determine the acute effect of ANG-(1-7) on vascular tone in isolated middle cerebral arteries (MCAs) from Sprague-Dawley rats fed a normal salt (NS; 0.4% NaCl) diet, 2) evaluate the ability of chronic intravenous infusion of ANG-(1-7) (4 ng·kg(-1)·min(-1)) for 3 days to restore endothelium-dependent dilation to acetylcholine (ACh) in rats fed a high-salt (HS; 4% NaCl) diet, and 3) determine whether the amelioration of endothelial dysfunction by ANG-(1-7) infusion in rats fed a HS diet is different from the protective effect of low-dose ANG II infusion in salt-fed rats. MCAs from rats fed a NS diet dilated in response to exogenous ANG-(1-7) (10(-10)-10(-5) M). Chronic ANG-(1-7) infusion significantly reduced vascular superoxide levels and restored the nitric oxide-dependent dilation to ACh (10(-10)-10(-5) M) that was lost in MCAs of rats fed a HS diet. Acute vasodilation to ANG-(1-7) and the restoration of ACh-induced dilation by chronic ANG-(1-7) infusion in rats fed a HS diet were blocked by the Mas receptor antagonist [D-ALA(7)]-ANG-(1-7) or the ANG II type 2 receptor antagonist PD-123319 and unaffected by ANG II type 1 receptor blockade with losartan. The restoration of ACh-induced dilation...Continue Reading

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Citations

Aug 2, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Gábor RaffaiJulian H Lombard
Oct 11, 2014·Cardiovascular Drugs and Therapy·Luís MendonçaPaulo Castro-Chaves
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Apr 16, 2016·Arteriosclerosis, Thrombosis, and Vascular Biology·Matthew J DurandAndreas M Beyer
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Dec 8, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Jessica R C PriestleyJulian H Lombard

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