Angiotensin-[1-7] attenuates kidney injury in experimental Alport syndrome.

Scientific Reports
Hong Sang ChoiEun Hui Bae

Abstract

Angiotensin-[1-7] (Ang-[1-7]) antagonize the actions of the renin-angiotensin-system via the Mas receptor and thereby exert renoprotective effects. Murine recombinant angiotensin-converting enzyme (ACE)2 was reported to show renoprotective effects in an experimental Alport syndrome model; however, the protective effect of direct administration of Ang-[1-7] is unknown. Here, we used Col4a3-/- mice as a model of Alport syndrome, which were treated with saline or Ang- [1-7]; saline-treated wild-type mice were used as a control group. The mice were continuously infused with saline or Ang-[1-7] (25 μg/kg/h) using osmotic mini-pumps. Col4a3-/- mice showed increased α-smooth muscle actin (SMA), collagen, and fibronectin expression levels, which were attenuated by Ang-[1-7] treatment. Moreover, Ang-[1-7] alleviated activation of transforming growth factor-β/Smad signaling, and attenuated the protein expression of ED-1 and heme oxygenase-1, indicating reduction of renal inflammation. Ang-[1-7] treatment further reduced the expression levels of inflammatory cytokines and adhesion molecules and attenuated apoptosis in human kidney cells. Finally, Ang-[1-7] downregulated TNF-α converting enzyme and upregulated ACE2 expression. Thus, treatm...Continue Reading

References

Oct 29, 1988·Lancet·F A FlinterM Bobrow
Dec 1, 1996·Genes & Development·D CosgroveG C Samuelson
Oct 12, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A RemuzziG Remuzzi
Nov 26, 1999·Kidney International·R SayersD Cosgrove
May 7, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Oliver GrossManfred Weber
Oct 4, 2005·Advances in Chronic Kidney Disease·Allison A Eddy
Mar 10, 2007·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Jun AgataKazuaki Shimamoto
Dec 25, 2009·American Journal of Physiology. Renal Physiology·Jiandong ZhangYufeng Huang
Mar 19, 1927·British Medical Journal·A C Alport
Dec 5, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Nicholas J A WebbChun Lam
Dec 19, 2012·Nature Reviews. Nephrology·Hiddo J Lambers HeerspinkGerjan J Navis
Jan 26, 2013·Journal of the American Society of Nephrology : JASN·Judy SavigeFrances Flinter
Dec 18, 2013·Journal of Molecular and Cellular Cardiology·Vaibhav B PatelGavin Y Oudit
May 7, 2014·Hypertension·Ricardo A Peña SilvaDavid M Hasan
Jan 1, 2013·Kidney International Supplements
Mar 18, 2015·The American Journal of Pathology·Eun Hui BaeJames W Scholey
Oct 18, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Mark C Chappell
Mar 21, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Ana Cristina Simões E Silva, Mauro Martins Teixeira
Aug 22, 2018·Clinical and Experimental Nephrology·Kandai NozuKazumoto Iijima
Aug 9, 2019·International Journal of Molecular Sciences·Sang Heon SuhEun Hui Bae

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Citations

Jul 30, 2020·Physiological Reviews·A SicaV Torri
Nov 26, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Girish PathangeyAmr E Abbas
Mar 19, 2021·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Trupti GhatageAudesh Bhat
May 7, 2020·Annales d'endocrinologie·Joachim AlexandreUNKNOWN 'Drugs, COVID-19' working group of the French Society of Pharmacology, Therapeutics
Jun 20, 2020·Thérapie·Joachim AlexandreUNKNOWN French Society of Pharmacology and Therapeutics (SFPT)
Aug 3, 2021·Clinical Science·Nayara Azinheira Nobrega CruzMariane Bertagnolli

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Methods Mentioned

BETA
genotyping
urine collection
ELISA
PCR
Smart Cycler

Software Mentioned

Corbett Research
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