Angiotensin-(1-7) attenuates the development of heart failure after myocardial infarction in rats

Circulation
Annemarieke E LootWiek H van Gilst

Abstract

The renin-angiotensin system (RAS) is a key player in the progression of heart failure. Angiotensin-(1-7) is thought to modulate the activity of the RAS. Furthermore, this peptide may play a part in the beneficial effects of angiotensin-converting enzyme inhibitors in cardiovascular disease. We assessed the effects of angiotensin-(1-7) on the progression of heart failure. Male Sprague-Dawley rats underwent either coronary ligation or sham surgery. Two weeks after induction of myocardial infarction, intravenous infusion of angiotensin-(1-7) (24 microg/kg per hour) or saline was started by minipump. After 8 weeks of treatment, hemodynamic parameters were measured, endothelial function was assessed in isolated aortic rings, and plasma angiotensin-(1-7) levels were determined. Myocardial infarction resulted in a significant deterioration of left ventricular systolic and diastolic pressure, dP/dt, and coronary flow. Raising plasma levels 40-fold, angiotensin-(1-7) infusion attenuated this impairment to a nonsignificant level, markedly illustrated by a 40% reduction in left ventricular end-diastolic pressure. Furthermore, angiotensin-(1-7) completely preserved aortic endothelial function, whereas endothelium-dependent relaxation in a...Continue Reading

References

May 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J M PfefferE Braunwald
Apr 1, 1994·The American Journal of Physiology·A MoriguchiC M Ferrario
Sep 1, 1993·Peptides·K KoharaC M Ferrario

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Citations

Dec 13, 2012·Hypertension·Pedro W Machado de AlmeidaSilvia Guatimosim
Apr 15, 2006·Circulation Research·Ingrid Fleming
Jan 9, 2008·Hypertension·Ping XuRobson A S Santos
May 8, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Sonja TesanovicRobert E Widdop
Apr 16, 2016·Circulation Research·Vaibhav B PatelGavin Y Oudit
Mar 8, 2003·Hypertension·Duncan John Campbell
Feb 7, 2015·Journal of the American Heart Association·Bruno Sevá PessôaAnton J M Roks
Jan 14, 2017·Arteriosclerosis, Thrombosis, and Vascular Biology·Brian R HoffmannAndrew S Greene
Sep 22, 2016·Journal of Diabetes Research·Stella BernardiBruno Fabris
Oct 1, 2003·Circulation·David B AverillCarlos M Ferrario
Mar 11, 2004·Current Hypertension Reports·Ruth E Hannan, Robert E Widdop
Jan 11, 2005·Experimental Physiology·Michael J KatovichMohan K Raizada
Apr 2, 2005·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Walmor C De Mello
Jun 18, 2005·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·A J Ferreira, R A S Santos
Jun 22, 2006·Physiological Genomics·Carlos Díez-FreireMohan K Raizada
Sep 8, 2006·Journal of Hypertension·Els A van der WoudenRobert H Henning
Oct 24, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Anderson J FerreiraRobson A S Santos
Apr 26, 2008·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Jasmina VaragicCarlos M Ferrario
Jan 9, 2009·Journal of Cardiovascular Pharmacology·Nadir UluWiek H van Gilst
Oct 2, 2008·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·B E LangeveldA Roks
Nov 29, 2008·The Journal of Pharmacology and Experimental Therapeutics·Leon D KluskensMarijke Haas
Aug 4, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Christoph H OsterreicherDavid A Brenner
Jan 7, 2010·Therapeutic Advances in Cardiovascular Disease·Anderson J FerreiraRobson A S Santos
Oct 22, 2010·American Journal of Physiology. Renal Physiology·Jorge F GianiFernando P Dominici
Aug 13, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Norihiro HayashiHiromi Rakugi
Dec 6, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Latronya T McCollumE Ann Tallant

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