Angiotensin-(1-7) inhibitory mechanism of norepinephrine release in hypertensive rats

Hypertension
Mariela M GironacciClara Peña

Abstract

Release of norepinephrine (NE) by the hypothalamic nuclei may contribute to regulation of sympathetic nervous system (SNS) activity. Angiotensin-(1-7) [Ang-(1-7)] has an antihypertensive effect and may decrease SNS activity. We tested the hypothesis that Ang-(1-7) inhibits the release of NE in hypothalami, via the Ang-(1-7) and angiotensin II type 2 (AT2) receptors, acting through a bradykinin (BK)/NO-dependent mechanism. Hypothalami from normotensive controls and spontaneously hypertensive rats (SHR) were isolated and endogenous NE stores labeled by incubating the tissues with [3H]NE. [3H]NE release from the hypothalami was stimulated by KCl in the presence or absence of Ang-(1-7) alone or combined with various antagonists and inhibitors. Ang-(1-7) significantly attenuated K+-induced NE release by hypothalami from normotensive rats but was more potent in SHR. The Ang-(1-7) receptor antagonist [D-Ala7]Ang-(1-7), the AT2 receptor antagonist PD 123319, and the BK B2) receptor antagonist icatibant all blocked the inhibitory effect of Ang-(1-7) on K+-stimulated NE release in SHR. The inhibitory effect of Ang-(1-7) disappeared in the presence of the NO synthase inhibitor N(G)-nitro-L-arginine methyl ester and was restored by the pre...Continue Reading

References

Sep 1, 1978·The Journal of Clinical Investigation·K Takeda, R D Buñag
Jul 24, 1992·Brain Research. Developmental Brain Research·K A MartinS Hockfield
Jan 1, 1996·Critical Reviews in Neurobiology·H Y YunT M Dawson
Jul 22, 1998·The American Journal of Cardiology·T LefèvreE Benveniste
Oct 9, 1998·Cardiovascular Research·S A Doggrell, L Brown
Aug 6, 1999·Cardiovascular Research·G Kojda, K Kottenberg
Oct 8, 1999·The Journal of Clinical Investigation·Y TsutsumiT Iwasaka
Jan 1, 2000·Cardiovascular Research·P Pagliaro
Mar 7, 2000·Journal of Hypertension·T Unger
Sep 1, 2000·Regulatory Peptides·R A SantosS P Andrade
Oct 3, 2001·Physiological Reviews·H E de Wardener
Jun 28, 2003·Proceedings of the National Academy of Sciences of the United States of America·Robson A S SantosThomas Walther
Jun 24, 2004·Molecular Pharmacology·Graeme Milligan

❮ Previous
Next ❯

Citations

Apr 29, 2010·Current Hypertension Reports·Huijing Xia, Eric Lazartigues
Jun 2, 2005·Regulatory Peptides·L S LaraC Caruso-Neves
Oct 15, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Jian-Zhong SunHong Liu
Apr 3, 2012·Antioxidants & Redox Signaling·Kaushik P Patel, Harold D Schultz
Sep 1, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Irving H ZuckerLie Gao
Nov 26, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Mirnela BykuThomas C Westfall
Dec 24, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ping XuEric Lazartigues
Nov 16, 2013·Biochemical Pharmacology·Donglin ZhuJingping Shi
Oct 25, 2008·Molecular and Cellular Endocrinology·Sharell M Bindom, Eric Lazartigues
Feb 3, 2009·Journal of Neurochemistry·María A Lopez VerrilliMariela M Gironacci
Nov 19, 2008·Journal of Neurochemistry·Huijing Xia, Eric Lazartigues
Aug 20, 2011·Alimentary Pharmacology & Therapeutics·J R A SkipworthH E Montgomery
May 16, 2014·Clinical Science·Mariela M GironacciBruno D Cerrato
Mar 28, 2013·Clinical Science·Mariela M GironacciBruno D Cerrato
Apr 7, 2012·International Journal of Hypertension·Fúlvia D MarquesRobson A S Santos
Apr 10, 2012·Brain Research·Bruno D CerratoMariela M Gironacci
Jun 6, 2007·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Ariel Héctor PolizioClara Peña
Aug 20, 2015·Therapeutic Advances in Cardiovascular Disease·Mariela M Gironacci
Sep 8, 2017·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Wenfeng ShangguanXuewen Wang
Oct 12, 2018·The Journal of Physiology·E N Bardsley, D J Paterson
May 15, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Jorge F GianiFernando P Dominici
Jul 17, 2019·American Journal of Hypertension·Kazushi Tsuda
May 20, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Yang-Kai WangWei-Zhong Wang
Aug 15, 2019·American Journal of Physiology. Renal Physiology·Anees A BandayMustafa Lokhandwala
Mar 3, 2007·Pharmacological Reviews·Noboru TodaTomio Okamura
Jan 20, 2018·Physiological Reviews·Robson Augusto Souza SantosMaria Jose Campagnole-Santos
May 15, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Lenice K BeckerMaria J Campagnole-Santos
Nov 4, 2010·Current Opinion in Nephrology and Hypertension·Carlos M Ferrario
Jun 5, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Priscila S GuimaraesMaria Jose Campagnole-Santos
Sep 30, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jorge GoldsteinMariela M Gironacci
Oct 12, 2019·American Journal of Hypertension·Daniela Medina, Amy C Arnold

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.