Angiotensin and NMDA receptors in the median preoptic nucleus mediate hemodynamic response patterns to stress.

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Julie A SchwartzMark M Knuepfer

Abstract

The brain renin-angiotensin system plays an important role in the regulation of arterial pressure in response to stress, in part due to activation of AT1 receptors in the hypothalamic median preoptic nucleus (MnPO) by endogenous angiotensin II (ANG II). N-methyl-d-aspartate (NMDA) receptors are also involved in the angiotensinergic signaling pathway through the MnPO. We investigated whether AT1 and NMDA receptors in the MnPO are responsible for variable hemodynamic response patterns to stress. Cocaine or startle with cold water evoked a pressor response in Sprague-Dawley rats due, in some rats [vascular responders (VR)], to a large increase in systemic vascular resistance (SVR) and, in other rats [mixed responders (MR)], to small increases in SVR and cardiac output (CO). Microinjection of the GABAA agonist muscimol into the MnPO to block synaptic transmission attenuated the cocaine- or stress-induced increase in SVR and the decrease in CO seen in VR without altering either response in MR. Likewise, administration of either an AT1 receptor antagonist, losartan, or an NMDA receptor antagonist, MK-801, attenuated the increase in SVR and the decrease in CO in VR in response to either cocaine (losartan and MK-801) or startle with co...Continue Reading

References

Aug 17, 1992·Neuroscience Letters·B BunnemannD Ganten
Oct 1, 1992·Postgraduate Medicine·R S Eliot
Dec 1, 1992·The American Journal of Physiology·D S ColombariJ V Menani
Dec 1, 1980·Journal of Neuroscience Methods·G PaxinosP C Emson
Oct 1, 1983·The American Journal of Physiology·J R HaywoodM J Brody
Sep 1, 1980·The American Journal of Physiology·G D FinkM J Brody
Mar 1, 1994·Frontiers in Neuroendocrinology·D W Brann, V B Mahesh
Jan 1, 1994·Neuroscience and Biobehavioral Reviews·J W Wright, J W Harding
Oct 1, 1993·Experimental and Molecular Pathology·M M KnuepferV W Fischer
Jul 23, 1998·Physiological Reviews·J T Fitzsimons
May 18, 1999·The American Journal of Physiology·E J WhalenA K Johnson
Jul 27, 1999·Pharmacology, Biochemistry, and Behavior·M M Knuepfer, P J Mueller
May 1, 2001·The Journal of Comparative Neurology·O EyigorL Jennes
Jun 19, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J R MullerM M Knuepfer
Aug 9, 2001·The Japanese Journal of Physiology·M J McKinleyR S Weisinger
Nov 14, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M M KnuepferK M Le
Apr 25, 2002·Hormones and Behavior·M K BreigeironG L Sanvitto
Feb 11, 2003·Pharmacology & Therapeutics·Mark M Knuepfer
Mar 7, 2003·European Journal of Pharmacology·John B WilliamsMark M Knuepfer
May 3, 2003·Neuroscience Letters·Kazuhiro SakamakiJunichi Tanaka
May 10, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ravi RamjeesinghChi-Hung Siu
Mar 1, 1963·British Heart Journal·J BROD
Jan 17, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·K J Latchford, A V Ferguson
Oct 2, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Michael D Hendel, John P Collister
Dec 29, 2004·Autonomic Neuroscience : Basic & Clinical·Gustavo Rodrigues PedrinoDébora Simões de Almeida Colombari
Apr 28, 2005·Clinical and Experimental Pharmacology & Physiology·Douglas G Whyte, Alan Kim Johnson

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