Angiotensin and other peptides in the control of water and sodium intake

Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character
J T Fitzsimons

Abstract

Several neuroactive peptides have been implicated in thirst and sodium appetite in different species; three peptides are considered here. The best established of these is the octapeptide angiotensin II, which when administered systemically or intracranially causes completely normal drinking behaviour in all vertebrates tested, including many mammals, four or five birds, one reptile and one bony fish. In the rat, in which the original experiments were carried out, injection of a few femtomoles of angiotensin II caused a brisk drinking response within a minute or so of injection at a time of day when the animal would usually be resting. The response is usually completed within 10 min and after the larger doses the amounts of water taken may approach what the animal would normally drink in the course of 24 h. Another response to intracranial angiotensin, seen so far only in the rat, is an increase in sodium appetite. This is slower in onset than thirst, lasts for many hours and the response tends to become greater with repeated injections of hormone. Naturally occurring increases in sodium appetite may be caused by angiotensin generated by the action of cerebral isorenin. A second neuroactive peptide that affects thirst is the und...Continue Reading

Citations

Jan 1, 1982·Physiology & Behavior·A S LevineJ E Morley
Dec 1, 1983·General and Comparative Endocrinology·J R Blair-WestJ F Nelson
Mar 1, 2011·Pharmacology, Biochemistry, and Behavior·Martin J Acerbo, Alan Kim Johnson
Jul 5, 2016·Frontiers in Nutrition·Simon N Thornton
Jul 1, 1982·Hypertension·J A Weyhenmeyer, M I Phillips
Feb 27, 2008·Pharmacoepidemiology and Drug Safety·Agnès SommetJean-Louis Montastruc
Dec 1, 1982·Epilepsia·A CovanisP M Jeavons
Jul 23, 1998·Physiological Reviews·J T Fitzsimons
Apr 15, 1988·The Journal of Comparative Neurology·F A MendelsohnM J McKinley

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