PMID: 4332372Feb 1, 1971Paper

Angiotensin and renin in rat and dog brain

The Journal of Experimental Medicine
C Fischer-FerraroS Finkielman


An enzyme with the characteristics of classical renin was isolated from brain extracts of nephrectomized dogs. This enzyme is thermolabile, nondialyzable, and forms a vasoconstrictive material when incubated with renin plasma substrate at pH 7. A short lasting pressor activity was also found in brain extracts of dogs and rats. This activity was due to a substance identified by chemical and pharmacological tests as angiotensin. Countercurrent distribution of brain extracts of rats showed that 38% of the pressor activity corresponded to angiotensin II and the remainder to angiotensin I. A remarkable correlation was found between angiotensin and norepinphrine concentrations in different portions of the encephalon of the dog.


Jun 21, 1969·Nature·S Finkielman, V E Nahmod
Dec 15, 1969·Experientia·M RothY Piquilloud
May 1, 1970·Proceedings of the Society for Experimental Biology and Medicine·K HaydukJ Genest
Mar 1, 1964·The Journal of Experimental Medicine·A B GOULDJ R KAHN

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