Angiotensin AT1 receptor-associated protein Arap1 in the kidney vasculature is suppressed by angiotensin II

American Journal of Physiology. Renal Physiology
Elisabeth DoblingerHayo Castrop

Abstract

Arap1 is a protein that interacts with angiotensin II type 1 (AT(1)) receptors and facilitates increased AT(1) receptor surface expression in vitro. In the present study, we assessed the tissue localization and regulation of Arap1 in vivo. Arap1 was found in various mouse organs, with the highest expression in the heart, kidney, aorta, and adrenal gland. Renal Arap1 protein was restricted to the vasculature and to glomerular mesangial cells and was absent from tubular epithelia. A similar localization was found in human kidneys. To test the hypothesis that angiotensin II may control renal Arap1 expression, mice were subjected to various conditions to alter the activity of the renin-angiotensin system. A high-salt diet (4% NaCl, 7 days) upregulated Arap1 expression in mice by 47% compared with controls (0.6% NaCl, P = 0.03). Renal artery stenosis (7 days) or water restriction (48 h) suppressed Arap1 levels compared with controls (-64 and -62% in the clipped and contralateral kidney, respectively; and -50% after water restriction, P < 0.01). Angiotensin II infusion (2 μg·kg(-1)·min(-1), 7 days) reduced Arap1 mRNA levels compared with vehicle by 29% (P < 0.01), whereas AT(1) antagonism (losartan, 30 mg·kg(-1)·day(-1), 7 days) enha...Continue Reading

References

Mar 14, 1986·Biochimica Et Biophysica Acta·E KitamuraY Shigeta
Jun 1, 1993·The American Journal of Physiology·W G PaxtonK E Bernstein
May 1, 1995·The Journal of Clinical Investigation·H F ChengR C Harris
Jul 1, 1997·The American Journal of Physiology·L M Harrison-BernardS S el-Dahr
Sep 14, 1999·The American Journal of Physiology·N MiyataA W Cowley
Oct 16, 2003·Biochemical and Biophysical Research Communications·Deng-Fu GuoTadashi Inagami
Apr 13, 2004·American Journal of Physiology. Renal Physiology·Hayo CastropJurgen Schnermann
Sep 18, 2004·Cell Biochemistry and Function·Bangalore R ShivakumarRaymond C Harris
Apr 21, 2005·The Journal of Clinical Investigation·Steven D CrowleyThomas M Coffman
Jul 11, 2006·American Journal of Physiology. Renal Physiology·Limeng ChenJurgen Schnermann
Jul 28, 2006·American Journal of Physiology. Cell Physiology·Puja K Mehta, Kathy K Griendling
Nov 9, 2006·Proceedings of the National Academy of Sciences of the United States of America·Steven D CrowleyThomas M Coffman
Jan 12, 2007·Journal of the American Society of Nephrology : JASN·Mona OppermannHayo Castrop
Aug 15, 2008·American Journal of Physiology. Renal Physiology·Soo Mi KimJurgen Schnermann
Aug 23, 2008·The Journal of Endocrinology·Márta SzaszákKevin J Catt
Dec 26, 2008·Kidney International·Frank SchwedaCharlotte Wagner
Jan 23, 2010·Journal of the American Society of Nephrology : JASN·Mona OppermannHayo Castrop
Apr 16, 2010·Physiological Reviews·Hayo CastropCharlotte Wagner
Aug 27, 2010·American Journal of Physiology. Renal Physiology·Hiromichi WakuiSatoshi Umemura

❮ Previous
Next ❯

Citations

May 17, 2012·Pflügers Archiv : European journal of physiology·Hayo Castrop
Jul 13, 2013·Critical Care : the Official Journal of the Critical Care Forum·Katharina MederleHayo Castrop
Nov 25, 2014·Expert Reviews in Molecular Medicine·Nathalie Thorin-Trescases, Eric Thorin
Feb 18, 2015·Current Opinion in Pharmacology·Daian Chen, Thomas M Coffman
Jan 7, 2015·Current Opinion in Pharmacology·Hayo Castrop
Jan 1, 2013·Cell Adhesion & Migration·Jaap D van BuulStephan Huveneers
Jul 6, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Maki Urushihara, Shoji Kagami
Oct 28, 2015·ELife·Jefferson J DoyleUNKNOWN MIBAVA Leducq Consortium
Jan 11, 2014·Critical Care : the Official Journal of the Critical Care Forum·Antoine Kimmoun, Bruno Levy
Nov 28, 2013·Current Opinion in Nephrology and Hypertension·L Gabriel Navar
Mar 3, 2020·Current Hypertension Reports·Kengo AzushimaAkira Nishiyama
Oct 14, 2021·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kouichi TamuraTakahiro Yamaji

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.