Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

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Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target

Abstract

Associated Clinical Trials

Rutgers COVID-19 Cohort Study

Effects of Discontinuing Renin-angiotensin System Inhibitors in Patients With COVID-19

Efficacy of Captopril in Covid-19 Patients With Severe Acute Respiratory Syndrome (SARS) CoV-2 Pneumonia (CAPTOCOVID)

COVID-19 Patient Positioning Pragmatic Trial

The Effect of Sitagliptin Treatment in COVID-19 Positive Diabetic Patients

Intramuscular Effect of Polymerized Type I Collagen on the Cytokine Storm in COVID-19 Patients

Managing Endothelial Dysfunction in COVID-19 : A Randomized Controlled Trial at LAUMC

Apelin; ACE2 and Biomarkers of Alveolar-capillary Permeability in SARS-cov-2 (COVID-19).

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Mechanisms of host receptor adaptation by severe acute respiratory syndrome coronavirus.

Simultaneous treatment of human bronchial epithelial cells with serine and cysteine protease inhibitors prevents severe acute respiratory syndrome coronavirus entry.

ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation.

Pharmacokinetics and pharmacodynamics of recombinant human angiotensin-converting enzyme 2 in healthy human subjects

Protease inhibitors targeting coronavirus and filovirus entry.

Mechanical Stress and the Induction of Lung Fibrosis via the Midkine Signaling Pathway

Angiotensin-(1-5), an active mediator of renin-angiotensin system, stimulates ANP secretion via Mas receptor

A pilot clinical trial of recombinant human angiotensin-converting enzyme 2 in acute respiratory distress syndrome

Recombinant human ACE2: acing out angiotensin II in ARDS therapy

TMPRSS2 Contributes to Virus Spread and Immunopathology in the Airways of Murine Models after Coronavirus Infection

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China.

Receptor Recognition by the Novel Coronavirus from Wuhan: an Analysis Based on Decade-Long Structural Studies of SARS Coronavirus.

Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding

Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission

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Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China.

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Single-cell RNA expression profiling of ACE2, the putative receptor of Wuhan 2019-nCov

Citations

COVID-19 and diabetes

ACE2 the Janus-faced protein - from cardiovascular protection to severe acute respiratory syndrome-coronavirus and COVID-19.

Inside the heart of COVID-19

Hypertension, the renin-angiotensin system, and the risk of lower respiratory tract infections and lung injury: implications for COVID-19.

Epidemiology, virology, and clinical features of severe acute respiratory syndrome -coronavirus-2 (SARS-CoV-2; Coronavirus Disease-19)

Coronavirus: Update Related to the Current Outbreak of COVID-19

A review on the cleavage priming of the spike protein on coronavirus by angiotensin-converting enzyme-2 and furin.

Association of Renin-Angiotensin System Inhibitors With Severity or Risk of Death in Patients With Hypertension Hospitalized for Coronavirus Disease 2019 (COVID-19) Infection in Wuhan, China.

Potential harmful effects of discontinuing ACE-inhibitors and ARBs in COVID-19 patients

Covid-19 and immunomodulation in IBD

Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System: Celebrating the 20th Anniversary of the Discovery of ACE2.

Airborne transmission of severe acute respiratory syndrome coronavirus-2 to healthcare workers: a narrative review

On Facing the SARS-CoV-2 (COVID-19) with Combination of Nanomaterials and Medicine: Possible Strategies and First Challenges

Cardiovascular disease and COVID-19: les liaisons dangereuses.

Off-target ACE2 ligands: possible therapeutic option for CoVid-19?

Is there an impact of the COVID-19 pandemic on male fertility? The ACE2 connection

Essential Oils as Antiviral Agents. Potential of Essential Oils to Treat SARS-CoV-2 Infection: An In-Silico Investigation

Three months of COVID-19: A systematic review and meta-analysis

The Heart and COVID-19: What Cardiologists Need to Know.

Age and sex differences in soluble ACE2 may give insights for COVID-19

COVID-19 and hypertension

Alternative splicing of ACE2 possibly generates variants that may limit the entry of SARS-CoV-2: a potential therapeutic approach using SSOs

A hypothesis for pathobiology and treatment of COVID-19: The centrality of ACE1/ACE2 imbalance.

Knowledge-based structural models of SARS-CoV-2 proteins and their complexes with potential drugs

Substituting Angiotensin-(1-7) to Prevent Lung Damage in SARSCoV2 Infection?

Impact of COVID-19 on the Cardiovascular System: A Review

COVID-19: ACE2centric Infective Disease?

Decreased Mortality of COVID-19 With Renin-Angiotensin-Aldosterone System Inhibitors Therapy in Patients With Hypertension: A Meta-Analysis

First comprehensive computational analysis of functional consequences of TMPRSS2 SNPs in susceptibility to SARS-CoV-2 among different populations.

The trinity of COVID-19: immunity, inflammation and intervention.

Targeting SARS-CoV-2 receptors as a means for reducing infectivity and improving antiviral and immune response: an algorithm-based method for overcoming resistance to antiviral agents.

Letter: intestinal inflammation, COVID-19 and gastrointestinal ACE2-exploring RAS inhibitors

Overview of transnational recommendations for COVID-19 transmission control in dental care settings.

Two hits to the renin-angiotensin system may play a key role in severe COVID-19

COVID-19 Presented With Deep Vein Thrombosis: An Unusual Presenting

Chloroquine and Hydroxychloroquine for the Prevention or Treatment of COVID-19 in Africa: Caution for Inappropriate Off-label Use in Healthcare Settings.

Letter: Thrombotic Neurovascular Disease in COVID-19 Patients.