Angiotensin-converting enzyme 2 is an essential regulator of heart function

Nature
Michael A CrackowerJosef M Penninger

Abstract

Cardiovascular diseases are predicted to be the most common cause of death worldwide by 2020. Here we show that angiotensin-converting enzyme 2 (ace2) maps to a defined quantitative trait locus (QTL) on the X chromosome in three different rat models of hypertension. In all hypertensive rat strains, ACE2 messenger RNA and protein expression were markedly reduced, suggesting that ace2 is a candidate gene for this QTL. Targeted disruption of ACE2 in mice results in a severe cardiac contractility defect, increased angiotensin II levels, and upregulation of hypoxia-induced genes in the heart. Genetic ablation of ACE on an ACE2 mutant background completely rescues the cardiac phenotype. But disruption of ACER, a Drosophila ACE2 homologue, results in a severe defect of heart morphogenesis. These genetic data for ACE2 show that it is an essential regulator of heart function in vivo.

References

Aug 1, 1991·Journal of Hypertension·M C ChappellC M Ferrario
Jan 1, 1980·Advances in Experimental Medicine and Biology·L T SkeggsJ R Kahn
Sep 15, 1996·Developmental Biology·R P Harvey
Dec 15, 1996·Genes & Development·N AzpiazuM Frasch
Oct 28, 1998·Physiological Reviews·G Heusch
Feb 5, 1999·Seminars in Neurology·M S Elkind, R L Sacco
Jul 16, 1999·Clinical and Experimental Pharmacology & Physiology·H J Jacob
Jan 5, 2000·Physiological Reviews·J P Rapp
Jan 22, 2000·Science·A M MurphyE Marbán
Jan 25, 2000·Circulation·O A Carretero, S Oparil
Sep 21, 2000·American Journal of Physiology. Renal Physiology·A J AllredD I Diz
Nov 14, 2000·Circulation Research·H Cai, D G Harrison
May 2, 2001·Proceedings of the National Academy of Sciences of the United States of America·F J GiordanoN Ferrara
Jun 8, 2001·Journal of Cardiovascular Pharmacology·F EnseleitT F Lüscher
Jan 1, 1988·Current Opinion in Cardiology·N K Hollenberg
Nov 27, 2001·Science·M StollH J Jacob

❮ Previous
Next ❯

Citations

Nov 12, 2005·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Wolfgang LiebJeanette Erdmann
Sep 22, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Keiji KubaJosef M Penninger
May 2, 2008·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Anderson J Ferreira, Mohan K Raizada
Apr 26, 2008·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Jasmina VaragicCarlos M Ferrario
Mar 13, 2012·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Friedrich C Luft
Jun 20, 2006·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Enrico PetrettoTimothy J Aitman
Mar 7, 2013·Pflügers Archiv : European journal of physiology·Michael Bader
May 2, 2008·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·C-Y LuL-M Huang
May 11, 2005·Cardiovascular Drugs and Therapy·Pasquale Pagliaro, Claudia Penna
Dec 8, 2011·Cardiovascular Drugs and Therapy·Osamu Tsukamoto, Masafumi Kitakaze
Mar 19, 2003·Current Hypertension Reports·Carlos M Ferrario
Aug 3, 2005·Current Hypertension Reports·Massimo VolpeErika Pagannone
Mar 28, 2008·Current Hypertension Reports·Jan WysockiDaniel Batlle
Sep 9, 2008·Current Hypertension Reports·María José SolerDaniel Batlle
Jan 13, 2004·Biochemical and Biophysical Research Communications·Ponraj PrabakaranDimiter S Dimitrov
Apr 19, 2005·The International Journal of Biochemistry & Cell Biology·Mazen KurdiGeorge W Booz
Mar 5, 2013·The International Journal of Biochemistry & Cell Biology·Ryusuke MomotaAiji Ohtsuka
Aug 22, 2013·Microbes and Infection·Thomas Perlot, Josef M Penninger
Feb 6, 2007·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Jamshid ShiraniVasken Dilsizian
Jul 13, 2005·Progress in Biophysics and Molecular Biology·Shant Der SarkissianMohan K Raizada
Mar 24, 2004·Trends in Genetics : TIG·Nobuyuki Takahashi, Oliver Smithies
May 26, 2005·Trends in Genetics : TIG·Ariel Darvasi
Sep 12, 2003·Journal of Molecular and Cellular Cardiology·Mary DonoghueRoger E Breitbart
Sep 12, 2003·Journal of Molecular and Cellular Cardiology·Barry London
Jan 18, 2003·Biochimica Et Biophysica Acta·Peter J TatnellJohn Kay
Nov 7, 2002·Current Biology : CB·Urs ErikssonJosef M Penninger
Aug 2, 2003·Trends in Endocrinology and Metabolism : TEM·Robert M Carey, Helmy M Siragy
Apr 15, 2003·Trends in Cardiovascular Medicine·Gavin Y OuditJosef M Penninger
Apr 5, 2003·The International Journal of Biochemistry & Cell Biology·Po Sing Leung, Mark C Chappell
Apr 5, 2003·The International Journal of Biochemistry & Cell Biology·Yusuke SuzukiJesus Egido
Apr 5, 2003·The International Journal of Biochemistry & Cell Biology·David Coates
Apr 12, 2003·Current Opinion in Pharmacology·Pedro D'Orléans-JusteJulie Labonté
Oct 29, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Adriana Pelegrini-da-SilvaAntonio R Martins
Nov 21, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Jelena KamilicHarry van Goor
Nov 21, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Takayoshi TsutamotoMinoru Horie
Dec 19, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Mark C Chappell
Feb 27, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Atsushi ShiotaHiromi Rakugi
Dec 3, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Luiza A RabeloMichael Bader
Oct 19, 2012·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Amy C ArnoldDebra I Diz
Mar 28, 2008·Nature Clinical Practice. Nephrology·Martin H de BorstGiuseppe Remuzzi
Apr 2, 2005·Nature Reviews. Genetics·Jonathan FlintRichard Mott

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.