Angiotensin-converting enzyme (ACE, I/D) gene polymorphism and susceptibility to abdominal aortic aneurysm or aortoiliac occlusive disease

The Journal of Surgical Research
Aleksandra KorczRyszard Słomski

Abstract

The purpose of this study was to examine the role of polymorphism in angiotensin converting enzyme gene (ACE, I/D) in the development of abdominal aortic aneurysm (AAA) or aortoiliac occlusive disease (AIOD). We investigated 829 individuals in 4 groups: AAA (n = 133), AIOD (n = 152), control (n = 152), and a random Polish population group (n = 392). ACE I/D gene polymorphism analysis was performed by polymerase chain reaction and gel electrophoresis. The genotype distribution was in Hardy-Weinberg equilibrium. The genotype distribution and allele frequency of ACE I/D were not significantly different between patients with AAA or AIOD and the control or the population group. Significant differences were found between the following groups: 1) hypertensive patients with AAA and normotensive patients with AAA (OR = 3.08 95% CI 1.22-7.79, P = 0.0147); 2) hypertensive patients with AAA and the population group (OR = 2.56; 95% CI 1.27-5.16, P = 0.0066). Since the majority of subjects were male, these associations were also true when only male hypertensive subjects with AAA were compared with male normotensive patients with AAA or to male population group. No relation of the ACE gene polymorphism to hypertension in the AIOD group was fo...Continue Reading

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Citations

Nov 30, 2010·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Vaiva LesauskaiteRimantas Benetis
Oct 16, 2015·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·D T BradleyA E Hughes
Dec 15, 2010·Annals of Vascular Surgery·Irene HinterseherHelena Kuivaniemi
Mar 30, 2010·Atherosclerosis·Smriti M KrishnaJonathan Golledge
Aug 1, 2014·Interactive Cardiovascular and Thoracic Surgery·Le-Gang HuangHai-Qing Wang
Jun 2, 2015·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·S ZuoW Guo
Oct 18, 2016·Genetic Testing and Molecular Biomarkers·Andrea Crkvenac GregorekSanja Dabelic
Jun 23, 2010·Angiology·Athanasios SaratzisGeorge D Kitas
Apr 17, 2013·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Gwan Gyu SongYoung Ho Lee
Aug 27, 2014·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Yan SongZifan Wang

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