PMID: 8582133Nov 1, 1995Paper

Angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism, and diabetic retinopathy in subjects with IDDM and NIDDM

Diabetic Medicine : a Journal of the British Diabetic Association
D K NagiP J Grant

Abstract

Angiotensin 1 converting enzyme (ACE) catalyses the step which generates angiotensin II, and also inactivates bradykinin, peptides which play a key role in modulating vascular tone. Plasma ACE levels are under genetic control and up to 50% of the variation is due to an insertion/deletion (I/D) polymorphism of ACE gene with highest levels found in DD homozygotes. Studies have shown an association of diabetic nephropathy and ischaemic heart disease with angiotensin converting enzyme gene polymorphism in subjects with diabetes. We examined the association between diabetic retinopathy and ACE gene insertion/deletion polymorphism in 363 subjects with NIDDM (aged 68.3 +/- 10.7 years; 201 male, 162 female), 186 subjects with IDDM (aged 42.4 +/- 15.0 years; 100 male, 86 female) and 98 controls. These subjects were characterized for ACE I/D polymorphism employing standard primers. Diabetic retinopathy was diagnosed by ophthalmoscopy through dilated pupils by an ophthalmologist and classified as non-proliferative or proliferative retinopathy. As expected, diabetic retinopathy was strongly associated with duration of diabetes (p < 0.001) in both IDDM and NIDDM. Any retinopathy was present in 51% subjects with IDDM and 49% of subjects with...Continue Reading

References

Apr 5, 1990·The New England Journal of Medicine·T J Merimee
Apr 1, 1989·Diabetologia·T DeckertA Kofoed-Enevoldsen
Dec 1, 1985·Medical Hypotheses·J H Connick, T W Stone
Jan 1, 1982·Diabetes·R D Leslie, D A Pyke
Mar 16, 1995·The New England Journal of Medicine·K LindpaintnerC H Hennekens
Sep 30, 1993·The New England Journal of Medicine·UNKNOWN Diabetes Control and Complications Trial Research GroupC Siebert

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Citations

Oct 20, 2001·Diabetes Research and Clinical Practice·M ArazA Sükrü Aynacioglu
Jul 3, 1999·Diabetic Medicine : a Journal of the British Diabetic Association·B KennonJ M Connell
Dec 3, 2002·Diabetes Technology & Therapeutics·David W Moskowitz
Nov 24, 2007·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·B Kennon, J M Connell
Feb 6, 2008·Progress in Retinal and Eye Research·Ning Cheung, Tien Y Wong
Nov 18, 2016·International Journal of Environmental Research and Public Health·Shasha LuoZhifeng Wu
Apr 24, 2018·Acta Ophthalmologica·Suzanne BroadgateVictor Chong
Sep 24, 2005·International Journal of Clinical Practice·I DegirmenciC Demirustu
May 2, 2003·Eye·K M Warpeha, U Chakravarthy

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