Angiotensin-converting enzyme activity and cognitive impairment during hypoglycaemia in healthy humans

Journal of the Renin-angiotensin-aldosterone System : JRAAS
U Pedersen-BjergaardB Thorsteinsson

Abstract

In type 1 diabetes increased risk of severe hypoglycaemia is associated with high angiotensin-converting enzyme (ACE) activity. We tested in healthy humans the hypothesis that this association is explained by the reduced ability of subjects with high ACE activity to maintain normal cognitive function during hypoglycaemia. Sixteen healthy volunteers selected by either particularly high or low serum ACE activity were subjected to hypoglycaemia (plasma glucose 2.7 mmol/L). Cognitive function was assessed by choice reaction tests. Despite a similar hypoglycaemic stimulus in the two groups, only the group with high ACE activity showed significant deterioration in cognitive performance during hypoglycaemia. In the high ACE group mean reaction time (MRT) in the most complex choice reaction task was prolonged and error rate (ER) was increased in contrast to the low ACE group. The total hypoglycaemic symptom response was greater in the high ACE group than in the low ACE group (p=0.031). There were no differences in responses of counterregulatory hormones or in concentrations of substrates between the groups. Healthy humans with high ACE activity are more susceptible to cognitive dysfunction and report higher symptom scores during mild h...Continue Reading

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Citations

Oct 21, 2009·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Adejoke B JegedeJill Maria Wecht
Aug 5, 2011·Scandinavian Journal of Clinical and Laboratory Investigation·Louise FærchBirger Thorsteinsson
Feb 4, 2009·Diabetes Research and Clinical Practice·L Ringholm NielsenE R Mathiesen
Feb 13, 2009·Diabetes Research and Clinical Practice·Peter Lommer KristensenBirger Thorsteinsson
Feb 9, 2012·Diabetic Medicine : a Journal of the British Diabetic Association·L RingholmE R Mathiesen
Mar 11, 2008·The American Journal of Medicine·Ulrik Pedersen-BjergaardBirger Thorsteinsson
Sep 1, 2009·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Thomas Høi-HansenBirger Thorsteinsson
Feb 4, 2011·The Journal of Clinical Endocrinology and Metabolism·Wendy A DavisTimothy M E Davis

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