Angiotensin-converting enzyme and angiotensin II receptor subtype 1 inhibitors restitute hypertensive internal anal sphincter in the spontaneously hypertensive rats

The Journal of Pharmacology and Experimental Therapeutics
Márcio A F de Godoy, Satish Rattan

Abstract

The present study determined the effects of the angiotensin-converting enzyme (ACE) inhibitor captopril and angiotensin II receptor subtype 1 (AT1-R) antagonist losartan on the internal anal sphincter pressures (IASP) in spontaneously hypertensive rats (SHR) versus normotensive Wistar-Kyoto rats (WKY). The SHR had significantly higher IASP (21.7 +/- 0.8 mm Hg) than the WKY (14.7 +/- 0.9 mm Hg), which was associated with the higher levels of angiotensin II (Ang II) in plasma (50.3 +/- 0.9 pg/ml) and in muscle bath perfusates (72.7 +/- 11.8 pg/ml) compared with the WKY (p < 0.05). Captopril and losartan decreased the IASP in SHR and WKY, but they were more potent in SHR. Captopril and losartan normalized the IASP in the SHR, whereas these agents may compromise rectoanal continence in the WKY. Reverse transcriptase-polymerase chain reaction and Western blots showed higher levels of angiotensinogen, renin, ACE, and AT1-R in the internal anal sphincter (IAS) of SHR. Ang II caused concentration-dependent contraction of IAS smooth muscle strips from WKY (pEC50 = 8.5 +/- 0.1) and SHR (pEC50 = 8.6 +/- 0.2). Losartan (100 nM) significantly (p < 0.05) inhibited this effect. From these data, we conclude that 1) hypertensive IAS in SHR is p...Continue Reading

References

May 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·S L EngelB Rubin
Jun 1, 1993·Circulation·K K GriendlingR W Alexander
Jul 1, 1996·The International Journal of Biochemistry & Cell Biology·L C KatwaK T Weber
Dec 17, 1998·The Journal of Endocrinology·P S LeungC Sernia
Jul 17, 1999·European Journal of Pharmacology·H AiharaS Satoh
Jun 26, 2001·Alimentary Pharmacology & Therapeutics·T A CookN J Mortensen
Feb 8, 2002·American Journal of Physiology. Cell Physiology·Marco A SotoRamón Latorre
May 11, 2004·World Journal of Gastroenterology : WJG·Zhong-Sheng ZhuShao-Liang Chen
Jul 6, 2004·Gastroenterology·Márcio A F De GodoySatish Rattan
Jan 18, 2005·Journal of Cardiovascular Pharmacology·Sandra Y FukadaAna M de Oliveira
Apr 20, 2005·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S Rattan
May 17, 2005·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yoshio HoritaShigeru Kohno

❮ Previous
Next ❯

Citations

Nov 15, 2011·Naunyn-Schmiedeberg's Archives of Pharmacology·Craig Comiter
Dec 6, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Márcio A F de GodoySatish Rattan
Feb 18, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Márcio A F de GodoySatish Rattan
Oct 30, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·María Cecilia AlvarezSusana M Mosca
Oct 31, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Xia ZhaoJun-Bao DU
Aug 12, 2009·Translational Research : the Journal of Laboratory and Clinical Medicine·Naoaki HaradaKenji Okajima
Aug 25, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Márcio A F de Godoy, Satish Rattan
Aug 14, 2015·Clinical and Experimental Hypertension : CHE·R Romero-NavaS Villafaña
Oct 13, 2015·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Shahram AlaRoja Qobadighadikolaei
Feb 25, 2021·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Arjun SinghSatish Rattan
Mar 10, 2021·Clinical and Experimental Hypertension : CHE·Malwina M Roszkowska-ChojeckaElzbieta Kompanowska-Jezierska
Jun 3, 2021·American Journal of Physiology. Gastrointestinal and Liver Physiology·Arjun Singh, Satish Rattan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Related Papers

American Journal of Physiology. Gastrointestinal and Liver Physiology
Márcio A F de Godoy, Satish Rattan
American Journal of Physiology. Gastrointestinal and Liver Physiology
Márcio A F de GodoySatish Rattan
American Journal of Physiology. Gastrointestinal and Liver Physiology
Márcio A F de Godoy, Satish Rattan
American Journal of Physiology. Gastrointestinal and Liver Physiology
Ping CongJose Behar
© 2022 Meta ULC. All rights reserved