Angiotensin-converting enzyme and angiotensinogen gene polymorphisms are non-randomly distributed in oral contraceptive-induced hypertension

Journal of Hypertension
P MulateroF Veglio

Abstract

Oral contraceptives (OC) usage increases serum angiotensinogen levels to three to five times normal and about 5% of these women develop arterial hypertension. The genetic contribution to this susceptibility to OC-induced hypertension is poorly understood. We have analyzed the genotypes of 149 hypertensive and 101 normotensive women using oral contraceptives, for three genetic polymorphisms in genes of the renin-angiotensin system: an insertion/deletion (I/ D) in the angiotensin converting enzyme (ACE) gene, the T235M polymorphism of the angiotensinogen gene (AGT) and a point mutation in its promoter. After cessation of oral contraception the mean arterial pressures of the hypertensive women were separable into two non-overlapping groups; 88 of the women remained hypertensive and 61 returned to normal blood pressure. Both groups of hypertensive women had a similarly higher frequency of hypertensive relatives than the normotensive women, but were otherwise similar. The 235T allele of AGT was significantly increased in frequency in the 61 oral contraceptive-inducible hypertensive women compared with the controls and the 88 women that remained hypertensive. The ACE I/D genotypes were similarly distributed within the three groups of...Continue Reading

References

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Citations

Apr 23, 2002·Pharmacogenomics·Paolo MulateroFranco Veglio
Aug 27, 2003·Journal of Physiological Anthropology and Applied Human Science·Yutaka TakashimaYu Sumiya
Jan 23, 2002·Pharmacoepidemiology and Drug Safety
Sep 28, 2006·The Journal of Clinical Endocrinology and Metabolism·Paolo MulateroMassimo Terzolo

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