Angiotensin-converting enzyme and angiotensinogen genes in patterns of left ventricular hypertrophy and in diastolic dysfunction

Clinical and Experimental Pharmacology & Physiology
K K WongM J West

Abstract

1. The association of different patterns of left ventricular hypertrophy and diastolic dysfunction with angiotensin converting enzyme (ACE) genotypes or angiotensinogen dinucleotide repeat alleles were studied in human subjects. 2. Three abnormal patterns of hypertrophy (remodelled, eccentric and concentric) were associated with a history of hypertension. The presence of remodelled or concentric hypertrophy was associated with diastolic dysfunction. 3. There was no difference between the frequencies of the ACE genotypes in normotensive and hypertensive subjects, in subjects with normal ventricles and those with different patterns of left ventricular hypertrophy, nor in subjects with normal and abnormal diastolic function. Similarly, there was no difference between the relative frequencies of AGT alleles in the same clinical subgroups. 4. We conclude that in this population of hospital patients, variants of the ACE and AGT genes do not contribute to the presence of different patterns of hypertrophy or to diastolic dysfunction.

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Citations

Aug 2, 2003·Heart & Lung : the Journal of Critical Care·Leslie C Hussey, Sonya Hardin
Dec 3, 2002·Diabetes Technology & Therapeutics·David W Moskowitz
Feb 19, 2008·British Journal of Clinical Pharmacology·Marcin Zakrzewski-JakubiakJacques Turgeon
Nov 17, 2004·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Gysèle S BleuminkBruno H Ch Stricker
Apr 22, 2011·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Esteban Orenes-PiñeroFrancisco Marín
Jan 29, 2011·Journal of the Renin-angiotensin-aldosterone System : JRAAS· Yu JinJan A Staessen
Nov 1, 2001·Journal of Human Hypertension·A StantonUNKNOWN Anglo-Scandinavian Cardiac Outcomes Trial
Mar 23, 2002·Journal of Hypertension·Robert H Fagard, Tatiana Kuznetsova
Aug 27, 2002·Journal of Hypertension·Mikolaj WinnickiUNKNOWN HARVEST Study Group

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