Angiotensin-converting enzyme and angiotensinogen gene polymorphisms and heart rate variability in twins

The American Journal of Cardiology
A BusjahnF C Luft

Abstract

Decreased heart rate variability (HRV) is associated with congestive heart failure, post-myocardial infarction, ventricular arrhythmias, sudden cardiac death, and advancing age. A deletion/insertion polymorphism in the angiotensin-converting enzyme (ACE) gene and a substitution (M235T) in the angiotensinogen gene have been associated with risk for heart disease. The aim of this study was to determine the heritability of HRV and related parameters in monozygotic and dizygotic twins and to assess the influence of ACE and angiotensinogen polymorphisms. We studied 95 MZ pairs and 46 DZ pairs. We measured HRV and related parameters, ACE and angiotensinogen levels, plasma norepinephrine, ACE, and angiotensinogen genotypes. We found that HRV and related parameters were significantly influenced by genetic variability, although nonshared genetic effects were also important. Angiotensinogen and plasma norepinephrine were generally correlated with decreased HRV, whereas ACE was correlated with perturbances of normal rhythmic HRV. Nevertheless, the DD ACE genotype was associated with increased HRV (p <0.05), whereas angiotensinogen polymorphisms had no effect. We conclude that HRV and related parameters are in part heritable. Interestingly...Continue Reading

References

May 27, 1976·Nature·M G ZieglerI J Kopin
Oct 2, 1992·Cell·X JeunemaitreJ M Lalouel
Jan 1, 1982·Annals of the New York Academy of Sciences·P J Schwartz, H L Stone
Jan 1, 1994·Nature Genetics·F SchächterD Cohen
Oct 1, 1996·Journal of Hypertension·A BusjahnF C Luft
Jan 1, 1994·Acta Crystallographica. Section D, Biological Crystallography·T C Terwilliger

❮ Previous
Next ❯

Citations

Oct 7, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Antoine U ViolaDerk-Jan Dijk
Feb 22, 2011·The International Journal of Cardiovascular Imaging·Serina A NeumannStephen B Manuck
Jul 17, 2003·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Sylvia RelandFrançois Carré
Jun 22, 2002·Clinical Physiology and Functional Imaging·Arja L T UusitaloRainer Rauramaa
Jul 16, 1999·Clinical and Experimental Pharmacology & Physiology·F C Luft
Jun 15, 2007·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Harold SniederJulian F Thayer
Mar 28, 2009·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Sergio CeruttiAndreas Voss
Sep 6, 2008·Neuroscience and Biobehavioral Reviews·Julian F Thayer, Richard D Lane
Nov 4, 2015·IEEE Journal of Biomedical and Health Informatics·Faezeh MarzbanradCraig McLachlan
Jun 14, 2006·Autonomic Neuroscience : Basic & Clinical·Andrew GrandinettiPhillip A Low
Dec 14, 2002·The American Journal of Cardiology·Jagmeet P SinghDaniel Levy
Oct 11, 2005·The American Journal of Cardiology·Xiaoling WangHarold Snieder
Mar 25, 2005·Psychophysiology·Nina KupperEco J C de Geus
Jun 16, 2015·Frontiers in Endocrinology·Ini-Isabée WitzelHabiba Alsafar
Dec 31, 2014·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Steffen SchulzVoss Andreas
May 20, 2016·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Jeanne E SavageJohn M Hettema
Jan 8, 2000·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·T WaltherA Voss
Sep 26, 2003·Physiological Measurement·T P Hutchinson
Apr 27, 2004·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Marie OlssonElias Eriksson
Mar 13, 2001·Hypertension·J TankA Busjahn
Apr 23, 2002·Journal of the Renin-angiotensin-aldosterone System : JRAAS·N PadmanabhanJ M Connell
Oct 20, 2004·Circulation·Nina H M KupperEco J C de Geus
Mar 7, 2001·Hypertension·F C Luft
Nov 15, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Marina BrinsukJens Jordan
Aug 13, 2011·Circulation. Cardiovascular Genetics·Christian HaarmarkJørgen K Kanters
Mar 24, 2005·Psychosomatic Medicine·Serina A NeumannStephen B Manuck
Aug 6, 2003·Medicine and Science in Sports and Exercise·Eco J C De GeusHarold Snieder
Jul 29, 2006·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·G GertenU Oberheide
Sep 30, 2006·Journal of Applied Physiology·D D O'LearyA R Hargens
Apr 3, 2007·American Journal of Physiology. Heart and Circulatory Physiology·A L T UusitaloJ Kaprio
Sep 6, 2003·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·Anthony S LeichtAndrew J Hoey
Feb 12, 2010·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Borwin BandelowPeter Falkai
Jun 10, 2011·European Radiology·Willi A KalenderMichaela C C Weigel
Feb 14, 2013·Pflügers Archiv : European journal of physiology·Peter Smetana, Marek Malik
Aug 28, 2010·Chronobiology International·Shih-Hsiang LoJung-Der Wang
Jul 3, 2020·Frontiers in Neuroscience·Steffen SchulzAndreas Voss

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Bradyarrhythmias

Bradyarrhythmias are slow heart rates. Symptoms may include syncope, dizziness, fatigure, shortness of breath, and chest pains. Find the latest research on bradyarrhythmias here.