PMID: 8592101Jan 1, 1996Paper

Angiotensin-converting enzyme and wound healing in diverse tissues of the rat

The Journal of Laboratory and Clinical Medicine
Y Sun, K T Weber

Abstract

Autoradiographic binding density of angiotensin-converting enzyme (ACE), an indirect measure of ACE activity, is markedly increased at sites of fibrous tissue that appear in the injured heart. This includes myocardial infarction (MI) caused by left coronary artery ligation; endocardial fibrosis of the interventricular septum and perivascular fibrosis of intramyocardial coronary arterioles of the right ventricle, each of which appear remote to MI; and pericardial fibrosis after pericardiotomy (without MI). Expressed in fibroblast-like cells found at each site of tissue repair, ACE may be common to tissue repair in the rat heart, irrespective of the etiologic basis of injury. To address this hypothesis and to determine whether this also applies to other tissues (skin and kidney), the present study was undertaken. ACE binding density was measured by quantitative in vitro autoradiography (125I-351A) in injured rat heart, skin, and kidney. Experimental observations included foreign-body fibrosis after placement of silk ligature in skin or myocardium, endomyocardial myocyte necrosis and fibrosis that accompanied isoproterenol administration (1 mg/kg sc x 2 days), and embolic infarction of the kidney as a result of mural thrombus of t...Continue Reading

References

Nov 1, 1977·Cardiovascular Research·P G CaspariP Harris
Jan 1, 1991·Circulation Research·H YamadaA O Mendelsohn
Oct 1, 1971·Biochimica Et Biophysica Acta·D W Cushman, H S Cheung
Nov 1, 1993·Journal of Molecular and Cellular Cardiology·P G VoldersM J Daemen

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Citations

Dec 31, 2002·Journal of Molecular and Cellular Cardiology·Claude Delcayre, Bernard Swynghedauw
Apr 5, 2003·The International Journal of Biochemistry & Cell Biology·Yao Sun, Karl T Weber
Jan 1, 1997·The International Journal of Biochemistry & Cell Biology·K T WeberL C Katwa
Oct 3, 1999·Kidney International·R MetzgerF E Franke
Apr 27, 2004·Journal of Hypertension·Karl T Weber
Jul 20, 2002·Journal of Cardiovascular Pharmacology·María Paz OcaranzaSergio Lavandero
Jul 11, 2000·Journal of Molecular and Cellular Cardiology·P Lijnen, V Petrov
Jan 29, 2016·Expert Review of Cardiovascular Therapy·Ritin BombKarl T Weber
Aug 18, 2009·Journal of Molecular and Cellular Cardiology·Yao Sun
Oct 18, 2005·The British Journal of Dermatology·U M SteckelingsM Artuc
Oct 21, 1999·The Journal of Surgical Research·J A LogingF G Spinale
May 10, 2017·Journal of Plastic Surgery and Hand Surgery·Christopher StephenStuart McKirdy
Dec 5, 2012·Nature Reviews. Cardiology·Karl T WeberIvan C Gerling
Apr 23, 2002·Journal of the Renin-angiotensin-aldosterone System : JRAAS·K T Weber, Y Sun
Apr 6, 2001·Clinical Cardiology·P CarsonH M Siragy
Mar 12, 2009·Langenbeck's Archives of Surgery·Uwe KlingeAnette Fiebeler
Jul 4, 2006·Physiological Reviews·Martin PaulReinhold Kreutz
Dec 7, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Jasmina VaragicJavier Díez
Oct 29, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·L A SchildmeyerR J Schwartz

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