Angiotensin-converting enzyme gene polymorphism in children with idiopathic nephrotic syndrome

American Journal of Nephrology
I-Jung TsaiFon-Jou Hsieh

Abstract

To investigate the genetic polymorphism of angiotensin-converting enzyme (ACE) insertion/deletion (I/D) in children with idiopathic nephrotic syndrome (INS), as well as its relationship with patient's clinical response to steroid therapy. Fifty-nine patients with INS were recruited and divided into 2 groups according to their clinical response to steroids: steroid-sensitive (SS) with 19 patients and non-SS with 40 patients, which was further divided into steroid-dependent (SD) and steroid-resistant (SR) groups with 35 and 5 patients, respectively. Seventy-nine children without previous renal diseases and negative proteinuria were enrolled as a control group. The genotypes for ACE I/D polymorphism, including DD, ID, and II, were analyzed. The distribution of ACE DD, ID, and II genotypes in INS patients were 52.5, 10.2 and 37.3%, respectively; the corresponding numbers for the control group were 2.5, 25.3 and 72.2%, respectively. Patients with INS had a significantly higher percentage of DD genotype (p <0.001) than the control group. This higher incidence of the DD genotype was observed in both the SS and non-SS groups. A higher percentage of the DD genotype in the non-SS group and in the SD group as compared to the SS group (bot...Continue Reading

References

Jun 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S M KorbetE J Lewis
Dec 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M M Schwartz, S M Korbet
Jul 1, 1993·Clinical Nephrology·A I PiquerasM J Dillon
Oct 1, 1996·Journal of the American Society of Nephrology : JASN·T MatsusakaI Ichikawa
Oct 20, 1996·Human Gene Therapy·T Marcel, J D Grausz
Aug 1, 1997·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·A BaggaR N Srivastava
Jan 5, 1999·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·A TakedaH Matsutani
Apr 1, 1999·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·U Querfeld
Aug 19, 1999·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·K HohenfellnerV Kon
Sep 29, 1999·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·D HaackP Vecsei
Jan 5, 2000·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·G NavisP E de Jong
May 17, 2001·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·K MaruyamaN Yoshikawa
Aug 7, 2001·Scandinavian Journal of Urology and Nephrology·A Al-EisaB S Srivastva
Sep 13, 2001·Molecular Biology of the Cell·A Al-HaddadS A Kuznetsov
Dec 1, 2001·Journal of the American Society of Nephrology : JASN·Gianluca CaridiGian Marco Ghiggeri
Dec 6, 2001·Current Problems in Pediatric and Adolescent Health Care·K D McBrydeW E Smoyer
Feb 13, 2003·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ferenc PappSándor Túri
Aug 16, 2003·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Colin Thomas WhiteDouglas George Matsell
Sep 19, 2003·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Lavjay Butani
Feb 27, 2004·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Faruk OktemTurgay Ispir

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Citations

May 10, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Hyun Jin ChoiHae Il Cheong
Apr 3, 2014·Nephro-urology Monthly·Mohammad HashemiAbdolkarim Moazeni-Roodi
Jun 5, 2013·The Journal of Clinical Hypertension·Retsilisitsoe R MoholisaEdward D Sturrock
Mar 18, 2010·British Journal of Clinical Pharmacology·Murat BasGeorg Kojda
Oct 25, 2011·Renal Failure·Belgin AlasehirliMithat Büyükçelik
Apr 27, 2010·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Maha Saber-AyadSanaa Abdel-Shafy
Jun 14, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Piero RuggenentiGiuseppe Remuzzi
May 10, 2017·Fetal and Pediatric Pathology·Maryam MonajemzadehNarjes Soleimanifar

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