PMID: 11920854Mar 29, 2002Paper

Angiotensin converting enzyme gene insertion/deletion polymorphism: case-control association studies in schizophrenia, major affective disorder, and tardive dyskinesia and a family-based association study in schizophrenia

American Journal of Medical Genetics
Ronnen H SegmanBernard Lerer

Abstract

Angiotensin converting enzyme (ACE) is a candidate gene for psychiatric disorders. We examined the frequency of a functional insertion/deletion (I/D) polymorphism in the 16th intron of the ACE gene (located on chromosome 17q23) in groups of patients with schizophrenia (n = 104 and 113), major depression (n = 55), and bipolar disorder (n = 87) compared to healthy control subjects (n = 87). There was no evidence for allelic or genotypic association of the polymorphism with any of the disorders or with tardive dyskinesia (TD) in patients with schizophrenia. In a sample of nuclear families (n = 61) made up of one or more patients with schizophrenia recruited with their parents, there was no evidence for biased transmission of ACE I/D alleles. Particularly in the case of schizophrenia, these findings do not support an association of the ACE I/D polymorphism with the phenotypes examined.

References

Aug 1, 1985·Neurology·V OksanenC Grönhagen-Riska
Jan 1, 1970·Acta Psychiatrica Scandinavica. Supplementum·G M Simpson, J W Angus
Jan 1, 1983·Modern Problems of Pharmacopsychiatry·T J CrowF Owen
Aug 28, 1980·The New England Journal of Medicine·F OwenT J Crow
Sep 1, 1994·The Journal of Clinical Investigation·B J MorrisA P Schrader
Jan 1, 1996·Advances in Experimental Medicine and Biology·T A JenkinsF A Mendelsohn
Mar 1, 1997·Journal of Neurochemistry·T A JenkinsS Y Chai
Feb 1, 1997·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Y KohnB Lerer
May 1, 1997·Progress in Neuro-psychopharmacology & Biological Psychiatry·K WahlbeckR Rimón
Jul 1, 1997·Psychiatric Genetics·R H SegmanB Lerer
Nov 4, 2000·American Journal of Human Genetics·S L LakeN M Laird
Apr 21, 2001·European Journal of Human Genetics : EJHG·S HorvathN M Laird

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Citations

Jun 14, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Brigitta BondyRainer Rupprecht
Jun 6, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Osamu OhmoriJun Nakamura
Oct 17, 2007·Molecular Psychiatry·S López-LeónC M van Duijn
Mar 24, 2006·Cell and Tissue Research·O von Bohlen und Halbach, D Albrecht
May 6, 2003·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Ari IlliEsa Leinonen
May 5, 2009·Neuroscience Letters·Juhani Akseli StewartEsa Leinonen
Mar 11, 2004·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Jorge CervillaSimon Lovestone
May 17, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Angela HeckMarcus Ising
May 11, 2012·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Fayaz SeifuddinPeter P Zandi
Jun 25, 2005·American Heart Journal·Mark P Donahue, Andrew S Allen
May 17, 2005·Medical Hypotheses·Katherine A RaymerCatherine R Price
Mar 26, 2004·The Pharmacogenomics Journal·D J MüllerJ L Kennedy
Dec 19, 2017·Translational Psychiatry·Han CaoEmanuel Schwarz
Aug 22, 2003·American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice·Manfred Schürmann
Feb 15, 2011·Nordic Journal of Psychiatry·Yan-Feng ZouFen Huang
Aug 22, 2014·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Gwan Gyu Song, Young Ho Lee

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