Angiotensin-converting enzyme inhibition and regional cerebral blood flow in acute stroke.

Journal of Cardiovascular Pharmacology
G WaldemarO B Paulson

Abstract

The effect of the angiotensin-converting enzyme (ACE) inhibitor captopril on regional cerebral blood flow (rCBF) was studied in 12 patients within 5 days after their first acute stroke. rCBF was studied by xenon-133 inhalation and single-photon emission computed tomography (SPECT) scan before and 1 h after oral administration of 25 mg captopril. No increase in rCBF was observed in any of the 12 patients included in the study. In only one patient was there a slight redistribution of blood flow in favor of the low-flow area, but the absolute flow value did not increase. Captopril did not cause any significant change in mean hemispheric blood flow, mean arterial blood pressure (MAP), or end-expiratory CO2 fraction (FECO2). The assumption that ACE inhibition might increase cerebral blood flow in the periinfarct zone and preserve some still viable brain tissue could not be verified in the present study.

Citations

Nov 19, 2010·Annals of Indian Academy of Neurology·Subhash Kaul
May 9, 2006·Critical Care Clinics·Denise H Rhoney, Xi Liu-DeRyke
Jul 1, 1997·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·H HashimotoH Naritomi
Jul 7, 2001·Stroke; a Journal of Cerebral Circulation·P BathN G Wahlgren
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Mar 20, 2008·Clinical Science·Yu-Sok KimJohannes J van Lieshout
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Nov 6, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Osian LlwydMartin Müller

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