Angiotensin converting enzyme inhibition in chronic allograft nephropathy

Transplantation
Julie LinJai Radhakrishnan

Abstract

Although angiotensin-converting enzyme inhibition has been shown to slow progression of chronic allograft nephropathy in animal models, no studies have examined its efficacy in humans. We retrospectively analyzed 63 patients with biopsy-proven chronic allograft nephropathy who had > or =6 months dialysis-free follow-up at our institution. A total of 32 patients treated for > or =6 consecutive months with angiotensin-converting enzyme inhibition and/or angiotensin-receptor blocker (ARB) therapy (group 1) were compared with 31 patients not on these agents (group 2). Except for a higher incidence of hypertension (100 vs. 78%, P=0.005) in group 1, there were no significant differences in baseline clinical characteristics at time of biopsy. With a mean follow-up time of 27 months in both groups, 6 of 32 (19%) group 1 patients vs. 12 of 31 (39%) group 2 reached the primary endpoint of > or =50% increase in serum creatinine (P=0.10). Mean time to primary endpoint was 46.6 months in group 1 vs. 32.7 months in group 2 (P=0.07). Three of 32 (9%) of group 1 patients vs. 8 of 31 (26%) of group 2 returned to dialysis during this time (P=0.11). Significantly fewer patients in group 1 reached the combined secondary endpoint of allograft failu...Continue Reading

References

Feb 1, 1996·Kidney International·Z A MassyB L Kasiske
Sep 1, 1996·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·U BarnasG Mayer
Jun 30, 1998·Journal of the American Society of Nephrology : JASN·G Remuzzi, N Perico
Oct 17, 1998·Journal of the American Society of Nephrology : JASN·S C AmuchasteguiG Remuzzi
Dec 5, 1998·Kidney International. Supplement·A Martínez-CastelaoJ M Grinyó
Feb 13, 1999·Kidney International·L C RacusenY Yamaguchi
Jul 21, 1999·Kidney International. Supplement·B L Kasiske
Jan 6, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·C E StigantJ S Zaltzman
Jun 1, 2000·Kidney International. Supplement·C Ponticelli
Mar 29, 2001·Journal of the American Society of Nephrology : JASN·Pablo IñigoFrancisca Rivera

❮ Previous
Next ❯

Citations

Apr 17, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Sangeeta Hingorani
Jan 8, 2008·Current Hypertension Reports·Daniel J Salzberg
Jul 3, 2003·Seminars in Nephrology·Arjang DjamaliJohn D Pirsch
Jul 29, 2009·Nature Reviews. Nephrology·Can Li, Chul Woo Yang
Aug 6, 2004·The New England Journal of Medicine·Biff F Palmer
Mar 20, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jeffrey S ZaltzmanRamesh Prasad
Oct 16, 2004·Current Opinion in Nephrology and Hypertension·Y Mun WooJohn S Gill
Jan 2, 2004·Transplantation·Daniel SerónUNKNOWN Spanish Chronic Allograft Nephropathy Study Group
Feb 24, 2010·Transplantation·James R CassutoPeter L Abt
Feb 26, 2013·Transplantation·Jean-Michel Halimi
May 20, 2004·Kidney International·Yvo W SijpkensLeendert C Paul
Jun 16, 2005·Kidney International·Simone A JoostenLeendert C Paul
Jan 10, 2006·Seminars in Dialysis·Elizabeth A Kendrick, Connie L Davis
Oct 16, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hyun Ho RyuByung Chul Shin
Apr 16, 2003·The American Journal of the Medical Sciences·Rubin ZhangEfrain Reisin
Sep 16, 2004·The American Journal of the Medical Sciences·Rubin ZhangEfrain Reisin
Jun 23, 2009·Transplantation Reviews·Abdallah S GearaReza Abdi
May 6, 2008·Transplantation Proceedings·P BravoP Ponce
Jul 10, 2007·Seminars in Nephrology·Nidyanandh VadivelAnil Chandraker
Jul 22, 2004·Pediatric Transplantation·Moro O SalifuEli A Friedman
Aug 13, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Jean-Michel HalimiYvon Lebranchu
Jun 16, 2005·Clinical Transplantation·Shinichi NishiFumitake Gejyo
Apr 16, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Nora FranceschiniRoslyn B Mannon
Jul 28, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J C RiceB J Nowicki
Jan 6, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M CantarovichM E Edwardes
Sep 12, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S HiremathG A Knoll
Mar 17, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R D Bloom, A M Doyle
Jan 3, 2006·Transplantation Proceedings·G Gómez MarquésA Purroy Unanua
Jan 18, 2006·Advances in Chronic Kidney Disease·Pankaj BalujaZoltan Laszik
Jun 21, 2005·Transplantation Proceedings·K OkaK Aozasa
Jul 22, 2004·Progress in Transplantation : Official Publication, North American Transplant Coordinators Organization ... [et Al.]·Meredith J Aull
Jan 25, 2012·Blood Purification·Heidi M Schaefer
Nov 28, 2007·Journal of the American Society of Nephrology : JASN·Roy D Bloom, Peter P Reese
Apr 28, 2006·Journal of the American Society of Nephrology : JASN·Ariela BenigniGiuseppe Remuzzi
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Arjang DjamaliBryan N Becker

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

© 2022 Meta ULC. All rights reserved